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师资队伍 > 教授
朴虎日

[个人简介]       

        延边大学药学院药物化学教授,博士生导师。中国药学会高级会员、中国药学会药物化学专业委员会委员、全国高等医药院校药学类规划教材编辑委员会委员、国家科技奖励评审专家、国家药品价格评审专家、中国药学会吉林省延边分会理事长。曾任延边大学医学部副部长兼药学院院长,全国高等医学教育学会药学教育研究会理事,长白山生物资源与功能分子教育部重点实验室副主任,延边大学学位评定委员会委员。    

        1957年10月出生于吉林省延吉市,1982年1月毕业于延边医学院药学系药学专业,1987年7月华西医科大学药学院药物化学专业研究生毕业, 1988年中国科学院成都有机化学研究所不对称合成实验室研修,1993日本城西大学药学部交换学者,1994年韩国首尔大学天然物研究所UNESCO青年交换学者,2002-2004美国Temple大学药学院访问学者。朴虎日教授主要从事于药物化学教学与科研,主要研究方向为心血管药物、抗菌药物和糖尿病药物的设计与合成研究,以及天然活性成分的结构修饰与抗肿瘤活性研究,是“Research and Reports in Medicinal Chemistry”刊物名誉编委、《中国药物化学杂志》编委,并担任“Bioorganic & Medicinal Chemistry Letter”、“European Journal of Medicinal Chemistry”、“Chemical Biology & Drug Design”、"Medicinal Chemistry Research"、“Fitoterapia" 、"Molecules"、等数种刊物的同行评审委员。曾经主持完成或正在研究的国家自然基金项目有4项 以及多项省级科研项目。曾获两项吉林省科技进步三等奖,发表了80多篇研究论文,其中40多篇SCI论文,总影响因子98,有4项专利。

(Tel: 0433-2435003(o), email: piaohr@ybu.edu.cn, address: 977 Gongyuan Road, Yanji City, Jilin Province, PR CHINA 133002)

[教学]       

        现从事药学专业、药物制剂专业本科教学及实验教学、毕业实习指导、硕士研究生《药物化学专论》、《高等药物化学实验》、《专业英语》以及博士研究生《手性药物合成》等课程教学。

[科研项目]

1. 国家自然科学基金项目《三唑并二氢喹啉衍生物的合成及正性肌力活性研究》 (2006.1-2008.12, 编号: 30560177) 24万

2. 国家自然科学基金项目《萘丙氨酸及查耳酮类PTP1B抑制剂的设计合成与生物活性研究》(2010.1-2012.12, 编号: 20962021)28万

3. 国家自然科学基金项目,“具有三元杂环的哌嗪及高哌嗪衍生物的设计合成与正性肌力活性研究”(2012.1—2015.12,批准号:81160381)50万元

4.国家自然科学基金项目,“国家罗丹宁杂环衍生物的设计合成及其脂烯酰基载体蛋白还原酶(FabI)抑制活性研究” 项目批准号: (2013.1-2016.12,批准号:81260468)55万元

5. “人参皂苷元PD及AD-2的结构修饰及抗肿瘤活性研究”, 吉林省自然科学基金项目,(2011.1-2013.12,批准号:201115235)4.0万

6. 吉林省科技厅项目《三唑并二氢喹啉衍生物的合成及正性肌力活性研究》(2006-2008, 编号: 20060567)

[科研奖项]

朴虎日,崔勋等“三唑并二氢喹啉衍生物的合成及正性肌力活性研究”2010吉林省科技进步三等奖. (编号:2010J30092)

[研究论文]

1. Chang-Ji Zheng, Li-Li Xu, Liang-Peng Sun, Jing Miao, Hu-Ri Piao*. Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. Eur J Med Chem. 2012; 58:112-116 (IF: 3.27)  

2. Chang-Ji Zheng1, Ming-Xia Song1, Liang-Peng Sun,Yan Wu, Lan Hong, Hu-Ri Piao*. Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. Bioorg & Med Chem Lett. 2012; 22:7024-7028 (IF: 2.65)

3. Xin Jin, Chang-Ji Zheng, Ming-Xia Song, Yan Wu, Liang-Peng Sun, Yin-Jing Li, Li-Jun Yu, Hu-Ri Piao*. Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. Eur J Med Chem. 2012; 56: 203-209 (IF: 3.27)

4. Tian-Yi Zhang; Liang-Peng Sun; Xue-Kun Liu; Xun Cui. Hu-Ri Piao*. In-vitro inotropic evaluation of 2-(4-substitutedbenzylpiperazin-1-yl)-N-(2-oxo-2,3-dihydrobenzooxazol-6-yl) acetamides. Med. Chem. 2012, 8, 1093-1098 (IF: 1.64)

5. Liang-Peng Sun, Li-Xin Gao, Wei-Ping Ma, Fa-Jun Nan, Jia Li*, Hu-Ri Piao* Synthesis and biological evaluation of 2,4,6-trihydroxychalcone derivatives as novel protein tyrosine phosphatase 1B inhibitors. Chem Biol Drug Des. 2012; 80: 584-590 (IF: 2.45)

6. 吴妍,马龙旭,牛天巍,孟凡领,崔勋,朴虎日*.2-(4-取代苄基-1,4-高哌嗪-1-基)-N-(5-溴喹喔啉-6-基)乙酰胺衍生物的合成及正性肌力活性研究.有机化学 2012, 32,1719-1724 (Chin J Org Chem, IF:0.55)

7. Peng Wang, Xiu-Li Bi, Yu-Mei Guo, Jia-Qing Cao, Shi-Jun Zhang, Hao-Nan Yuan, Hu-Ri Piao*, Yu-Qing Zhao*. Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives. Eur J Med Chem. 2012; 58:137-145. (IF: 3.27)

8. Xu LL, Zheng CJ, Sun LP, Miao J, Piao HR. Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. Eur J Med Chem. 2012; 48: 174-8 (IF: 3.27)

9. Liu XK, Ye BJ, Wu Y, Nan JX, Lin ZH, Piao HR*. Synthesis and Antitumor Activity of Dehydroepiandrosterone Derivatives on Es-2, A549, and HepG2 Cells in vitro. Chem Biol Drug Des. 2012 79(4): 523-529 (IF: 2.45)

10. ZH Chen, LP Sun, W Zhang, Q Shen, LX Gao, J Li*, HR Piao*. Synthesis and biological evaluation of heterocyclic ring-substituted chalcone derivatives as novel inhibitors of protein tyrosine phosphatase 1B. B Korean Chem Soc 2012 33(5), 1505-1508 (IF: 0.87)

11. Yan Wu, Long-Xu Ma, Tian-Wei Niu, Xun Cui*, Hu-Ri Piao*. Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties. Bioorg & Med Chem Lett. 2012 22: 4229-4232 (IF: 2.65)

12. Ming-Xia Song, Chang-Ji Zheng, Xian-Qing Deng, Qing Wang, Shao-Pu Hou, Ting-Ting Liu, Xiao-Lan Xing, Hu-Ri Piao*. Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. Eur J Med Chem. 2012; 54: 403-412 (IF: 3.27)

13. 孟凡领,郑昌吉,李因晶,孙良鹏,刘学坤,朴虎日*.含噻唑烷二酮-3-乙酸结构查尔酮衍生物的合成及抗菌活性的研究.有机化学 2012, 32, 183-188 (Chin J Org Chem, IF:0.55)

14. Xue-Kun Liu, Bai-Jun Ye, Yan Wu, Zhen-Hua Lin, Yu-Qing Zhao, Hu-Ri Piao*. Synthesis and anti-tumor evaluation of panaxadiol derivatives. Eur J Med Chem. 2011 46, 1997-2002 (IF: 3.27)

15. Chang-Ji Zheng, Sheng-Ming Jiang, Zhen-Hua Chen, Bai-Jun Ye, Hu-Ri Piao*. Synthesis and anti-bacterial activity of some heterocyclic chalcone derivatives bearing thiofuran, furan, and quinoline moieties. Arch Pharm (Weinheim). 2011 344(10):689-95 (IF: 1.78)

16. Xiao-Fang Liu, Chang-Ji Zheng, Xue-Kun Liu, Hu-Ri Piao*. Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. Eur J Med Chem. 46 (2011) 3469-3473 (IF: 3.27)

17. Liang-Peng Sun, Qiang Shen, Hong-Hua Piao, Li-Xin Gao, Jia Li *, Hu-Ri Piao *, Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. Eur J Med Chem. 2011 46(9):3630-8 (IF: 3.27)

18. Jun-Ming Zhao, Ning Li, Hong Zhang, Chun-fu Wu, Hu-Ri Piao, and Yu-Qing Zhao, Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities Bioorg Med Chem Lett. 2011 21(3): 1027-31

19. Bai-Jun Ye,  Xue-Kun Liu, Sheng-Ming Jiang, Xun Cui*, and Hu-Ri Piao*. Synthesis of 2-(4-Substitutedbenzyl-[1,4]diazepan-1-yl)-N-(1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides as Inotropic Agents. Chemical Biology &Drug Design. 2011 77, 98-103.

20. Zhen-Hua Chen, Chang-Ji Zheng, Liang-Peng Sun, Hu-Ri Piao * Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity Eur J Med Chem. 2010 45,5739-5743

21. Sheng-Ming Jiang, Tian-Yi Zhang, Bai-Jun Ye, Xun Cui*, and Hu-Ri Piao*. Synthesis and Positive Inotropic Evaluation of 2-(4-(4-Substitutedbenzyloxy)-3-methoxybenzyl)-1,4-diazepan-1- yl)-N-(4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides. Arch Pharm (Weinheim). 2010 343(11-12):700-5

22. Kun Yang, Liang-Peng Sun, Ji-Yong Liu, Xun Cui*, Hu-Ri Piao*, Synthesis of 2-(4-substituted methyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation. Bioorg Med Chem Lett. 2010 20, 4464-7.

23. Ying Lan, Huri Piao,* Xun Cui.* Positive inotropic effect of PHR0007(2-(4-(4-(Benzyloxy)-3-methoxybenzyl)piperazin-1-)-N-(1-methyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamide) on atrial dynamics in beating rabbit atria. Drug Discov Ther.  2009; 3(6):272-277.

24. Ji-Yong Liu, Hai-Ling Yu, Zhe-Shan Quan, Xun Cui*, Hu-Ri Piao*. Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl) piperidine-4-carboxamides.. Bioorg Med Chem Lett. 2009 19: 2392-5

25. Xue-Kun Liu, Xun Cui, Lan Hong, Liang-Peng Sun, Zhe-Shan Quan, Hu-Ri Piao*. Synthesis of 2-(4-substitutedmethylpiperazin-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation. Eur J Med Chem. 2009 44: 3027-3031 .

26. Ting Ting Li, Ling Zhang, Zhe-Shan Quan, Hai Bo Zhu, Hu-Ri Piao*. Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-dihydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy) propan-2-ol derivatives. Chin Chem Lett, 2009, 20 (2): 175-177.

27. Jing-Yuan Li, Xun Cui, Xue-Kun Liu, Lan Hong, Zhe-Shan Quan and Hu-Ri Piao*. Synthesis and Positive Inotropic Evaluation of 2-(4-(4-Substitutedbenzyloxy)-3-methoxybenzyl)- 1,4-diazepan-1- yl)-N-(4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides. Arch Pharm (Weinheim). 2008 Nov 12;341(12):794-799 

28. Chun-Bo Zhang, Xun Cui, Lan Hong, Zhe-Shan Quan, Hu-Ri Piao*. Synthesis and positive inotropic activity of N-(4,5-Dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)aceta mide derivatives. Bioorg Med Chem Lett. 2008 18: 4606-9

[专利]

朴虎日;孙良鹏;苗京;徐丽丽. 含3-羧烷基罗丹宁衍生物的抗菌化合物,中国专利,申请号:201110213051.9

朴虎日;崔勋;吴妍. 用作正性肌力药物的三唑并喹啉衍生物. 中国专利,申请号:201110321135.4

朴虎日;郑昌吉;郭萌;宋明霞. 含喹啉或吡唑杂环罗丹宁结构的抗菌化合物. 中国专利,申请号:201210272644.7