学院概况 机构设置 师资队伍 人才培养 科学研究 党建工作 学生园地 毕业实习
师资队伍 > 教授
全哲山

 

 

 

【研究方向】

  1. 天然药物结构修饰与药理活性研究

  2. 抗癫痫药和抗抑郁药设计与合成

 

【学习经历】

1981.9-1985.7 延边医学院,药学专业,学士学位

1989.9-1991.7 北京医科大学,药物化学专业,硕士学位

2003.9-2006.2 韩国圆光大学,药物化学专业,博士学位

 

【工作经历】

1981.7-1989.8 延边医学院,药学系,助教

1991.7-1996.12 延边医学院,药学系,讲师

1997.1-2000.12 延边大学,药学院,副教授

1997.1-1997.6  日本城西大学,药学系,访问学者

2001.1-现在   延边大学,药学院,教授

2008.1-现在   延边大学,药学院,博士导师

2012.1-现在   延边大学,药学院,二级教授

【获得荣誉】

    2008年吉林省有突出贡献中青年专业技术人才

    2012年获吉林省拔尖创新人才(第一层次)

    2014年吉林省长白山学者特聘教授

    2014年吉林省高级专家

【社会兼职】

    1.国家自然科学基金委员会评审专家

    2.教育部学位论文评审专家

    3.吉林、河北、内蒙古等科技项目评审专家

    4.中国药物化学杂志编委

    5.延边大学医学学报编委

    6.吉林省药学会药物化学专业委员会副主任委员

【科研项目】 

 

项目名称(编号)

项目来源

承担时间

承担顺序

1

抗癫痫候选药物W112的研究(2012ZX09103-101-044)

国家重大科技专项

2012-2015

1

2

抗癫痫一类新药-Q808胶囊的临床前研究(2011ZX09102-003-03)

国家重大科技专项

2011-2013

2

3

喹啉并四唑类抗抑郁先导化合物的发现与结构优化(81360468)

国家自然科学基金

2014-2017

1

4

喹啉并三唑酮类衍生物的合成及抗癫痫作用研究(81160382)

国家自然科学基金

2012-2014

1

5

吡唑烷酮类衍生物的合成及抗癫痫作用研究(30460151)

国家自然科学基金

2005-2007

1

6

喹喔啉酮衍生物的合成及抗癫痫作用研究(30760290)

国家自然科学基金

2008-2010

1

7

二苯甲基哌嗪类衍生物的合成和抗癫痫作用及作用机制研究(30860340)

国家自然科学基金

2009-2011

1

 

【获奖】

1.“抗癫痫候选药物Q808的研究”, 吉林省科学技术进步二等奖,吉林省科技厅,2011年,第一名。

2.“吡唑烷酮类抗癫痫先导化合物的寻找与结构优化”,吉林省科学技术进步三等奖,吉林省政府,2006年, 第一名。 

3.三唑类衍生物的合成及抗癫痫作用研究, 吉林省自然科学学术二等奖,吉林省科学技术协会,2014年,第一名。 

4. “7-烷氧基-4,5-二氢[1, 2, 4]三唑并[4, 3-a]喹啉的开链物4-(4-烷氧基苯基)-3-乙基-4H-1,2,4-三唑衍生物的合成及惊厥作用”,吉林省自然科学学术二等奖,吉林省科学技术协会,2009年,第一名。

5. “喹啉及酞嗪并杂环衍生物的合成及抗癫痫作用研究”,吉林省优秀博士论文,2012年,获奖人:孙先宇,指导教师:全哲山

6.“3,4-二氢-苯并[f][1,4]氧氮杂卓衍生物的抗惊厥活性研究”,吉林省优秀硕士论文,2011年,获奖人:邓先清,指导教师:全哲山

7.“三唑环类化合物的合成及其活性的研究”,吉林省优秀硕士论文,2010年,获奖人:陈敬,指导教师:全哲山

8.“7-苄氨基-2H-苯并[b][1,4]氧嗪-3(4H)-酮衍生物的合成及抗惊厥活性评价,2010年,获奖人:朴钟太,指导教师:全哲山  

【申请专利】
1. 全哲山,金洪光,谢志峰,孙先宇,金云哲。用作抗癫痫药的1,2,4-三唑并[4,3-a]喹啉-1-酮衍生物及其可药用盐。中国专利,ZL200610016578.1,2006-07-26(已授权)

 2. 全哲山,邓先清,关丽萍,魏成喜,孙先宇。用作抗抑郁药的5-烷氧基-四唑并[1,5-a]喹啉酮衍生物及其可药用盐,中国专利,200910004690.7

 3. 全哲山,关丽萍,孙先宇,魏成喜,张昌浩。用作抗癫痫药的6-(取代苯氧基)-四唑并[5,1-a]酞嗪衍生物及其可药用盐,中国专利,200810165734.X,2010,3,24(已授权)

 4. 全哲山,宫国华,魏成喜,邓先清,孙先宇。一类用作抗癫痫药的化合物及其可用药用盐,中国专利,201110170659.8,2012,12,19

 5. 全哲山,于海玲,邓先清。化合物 6-(4-氯苯氧基)-四唑并[5,1-a]酞嗪在制备治疗抑郁症药物中的应用,中国专利,201210232371.3,2013,01,23

 6. 全哲山,邓先清,刘大川。用作抗癫痫药的7-烷氧基-[1,2,4]三唑并[3,4-b]并噻唑-3(2H)-酮衍生物及其制备方法,中国专利,201210316306.9,2013,01,23

7. 全哲山, 李伟,芦志刚,于赢洲,邓先清. 一种6-(4-氯苯氧基)-四唑并[5,1-a]酞嗪的多晶型制备方法及其应用.申请号, 2014100597686, 2014.05.28

 8. 李伟, 全哲山, 梅雪峰, 董方言, 叶婵娟, 芦志刚,于赢洲。 一种用于抗癫痫病药物的Q808固体分散体及其制备方法。申请号,2014100642893,2014.05.28 

 9.全哲山,王世本,温翔。用作抗炎药的9-烷基-5,8,9,10-四氢-4H-7-氧杂-2,3,9,11b-四氮杂-环戊二烯并[α]蒽衍生物及其制备方法。申请号,201410469632.2

 

   【发表论文】        

2018年

113. Qing-Kun Shen, Zheng-Ai Chen, Hong-Jian Zhang, Jia-Li Li, Chuan-Feng   Liu, Guo-Hua Gong & Zhe-Shan    

Quan. Design and synthesis of novel oridonin analogues as potent anticancer agents. J Enzyme Inhib Med Chem,  2018, 33(1), 324–333

112. Ying-Quan FANG, Hong-Jian ZHANG, Yang REN, Zhe-Shan QUAN.Synthesis and Evaluation of the    Antidepressant Activity of Quinoxaline-2,3(1H,4H)-dione Derivatives. Lat. Am. J. Pharm,2018,37 (1), 1-5

2017年 11篇

111. Qing-Kun Shen, Chuan-Feng Liu, Hong-Jian Zhang, Yu-Shun Tian, Zhe-Shan Quan. Design and synthesis of new triazoles linked to xanthotoxin for potent and highly selective anti-gastric cancer agents. Bioorg Med Chem Lett. 2017, 27(21), 4871-4875

110. Hong-Jian Zhang_, Guo-Rui Zhang_, Hu-Ri Piao and Zhe-Shan Quan. Synthesis and characterisation of celastrol derivatives as potential anticancer Agents. J Enzyme Inhib Med Chem, 2017, 33(1), 190-198

109. Guo-Rui Zhang, Yang Ren, Xiu-Mei Yin and Zhe-Shan Quan. Synthesis and Evaluation of the Anticonvulsant Activities of New 5-substitued-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one Derivatives. Lett Drug Des Dis, 2017, DOI 10.2174/1570180814666170619094408

108. Xiang-Jun Liu,  Hong-Jian Zhang,  Zhe-Shan Quan. Synthesis and evaluation of the anticonvulsant activities of 2,3-dihydrophthalazine-1,4-dione derivatives. Med Chem Res, 2017, DOI 10.1007/s00044-017-1896-8

107. Zhang Haiming Zhang Hongjian, Tian Yushun Quan, Zheshan*. Synthesis and Anticonvulsant Activity Evaluation of Phthalazine and Heterocyclic Derivatives. Chin J Org Chem. 2017, 37, 2322-2327

106. Hong-Jian Zhang, Xiu-Zhi Wang, Qi Cao, Guo-Hua Gong, Zhe-Shan Quan. Design, synthesis, anti-inflammatory activity, and molecular docking studies of perimidine derivatives containing triazole. Bioorg Med Chem Lett, 2017, 27, 4409–4414

105. Liu CF, Shen QK, Li JJ, Tian YS, Quan ZS. Synthesis and biological evaluation of novel 7- hydroxy- 4-phenylchromen-2-one–linked to triazole moieties as potent cytotoxic agents. J Enzym Inhib Med Chem, 2017, 32(1), 1111–1119

104. Xiang Li, Hong-Jian Zhang, Qing Wang, Dian-Wen Zhang, Di Wu, Wei Li,*and Zhe-Shan Quan. Current Study of the Mechanism of Action of the Potential Anti-Epileptic Agent Q808.  Moleculers, 2017, 22, 1134

103. Miao-Miao Li, Zheng-er Jiang, Ling-Yun Songa, Zhe-Shan Quan, Hai-Ling Yu. Antidepressant and anxiolytic-like behavioral effects of erucamide, a bioactive fatty acid amide, involving the hypothalamus–pituitary–adrenal axis in mice. Neurosci Lett, 2017, 640: 6–12

102. Mi C, Ma J, Wang KS, Zuo HX, Wang Z, Li MY, Piao LX, Xu GH, Li X, Quan ZS, Jin X. Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways. J Ethnopharmacol, 2017, 203: 27-38

101. Hong-Jian Zhang, Yan-Fei Li, Qi Cao, Yu-Shun Tian, Zhe-Shan Quan. Pharmacological evaluation of 9,10-dihydrochromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives as potent anti-inflammatory agent. Pharmacol Rep, 2017, 69(3), 419-425

2016年9篇

100. Li, Yan-Fei; Zhang, Hong-Jian; Quan, Zhe-Shan. Synthesis and anti-inflammatory activity evaluation of novel 3-alkyl-6-(4H-1,2,4-triazol-4-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazine derivatives. Med Chem Res, 2016, 25( 10)  : 2280-2288

99. Yang Ren, Qing-Kun Shen, Ming-Ming Ding, Xiu-Mei Yin*, Zhe-Shan Quan. Synthesis and Anticonvulsant Activities of 4-Alkoxyl-[1,2,4]    Triazolo[4,3-a]Quinoxaline Derivatives. Lat Am J Pharm,  2016, 35(10), 2169-2175.

98. Zhang HJ, Shen QK, Jin CM, Quan ZS. Synthesis and Pharmacological Evaluation of New 3,4-Dihydroisoquinolin Derivatives Containing Heterocycle as Potential Anticonvulsant Agents. Moleculers, 2016, 21(12). pii: E1635.

97. Zhang, Hong-Jian; Wang, Shi-Ben; Wen, Xiang. Jin-Zi Li, Zhe-Shan Quan. Design, synthesis, and evaluation of the anticonvulsant and antidepressant activities of pyrido[2,3-d]pyrimidine derivati. Med Chem Res. 2016, 25(7): 1287-1298

96. Liu DC, Gong GH, Wei CX, Jin XJ, Quan ZS. Synthesis and anti-inflammatory activity evaluation of a novel series of 6-phenoxy-[1,2,4]triazolo[3,4-a]phthalazine-3-carboxamide derivatives. Bioorg Med Chem Lett, 2016, 26(6), 1576-1579

95. Liu CF, Zhang HJ and Quan ZS*.Synthesis and Anticonvulsant Activity of Novel 3-(2- (4H-1,2,4- triazol- 4-yl)ethyl)-1-alkyl-1H-indole Derivatives. Lett Drug Des Dis, 2016, 13(8), 833-839

94. Liu DC, Zhang HJ, Jin CM, Quan ZS. Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents. Molecules. 2016 , 21(3). pii: E164.

93. Fu-Jun Pan, Shi-Ben Wang, Da-Chuan Liu, Guo-Hua Gong and Zhe-Shan Quan. Synthesis of 4-Phenylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidine-5(4H)-one Derivatives and Evaluation of Their Anti-inflammatory Activity. Lett Drug Des Dis, 2016, 13(2), 141-148

92. Guan LP, Quan ZS. 3,4-DHQLO and Triazole and its Related Analogues with Anticonvulsant Effects. Mini Rev Med Chem. 2016, 16(4), 323-342

2015

91. Wei CX, Cao Q, Gong GH, Jin QH, Quan ZS. The regulating inotropic activity of 6-substituted-oxy-[1,2,4]triazolo[3,4-a]phthalazine. Lat Am J Pharm,  2015, 34(8), 1672-1676

90. Hong-JianZhang1,PengJin2,Shi-BenWang1,Fu-NanLi3,Li-PingGuan4, andZhe-ShanQuan. Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-2[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one   and Its Derivatives. Arch Pharm, 2015, on line

89. Hui Li, Dong-Zhou Kang*, Shi-Ben Wang, Guo-Hua Gong, Zhe-Shan Quan. Synthesis and elvaluation of the anticonvulsant activity of  9-alkyl-2,9-dihydro-3H-1,2,4-triazolo[4,3-a]benzimidazole-3-one deriva. Lat Am J Pharm, 2015, 34(1), 5-12

88. Xiang Wen, Shi-Ben Wang, Da-Chuan Liu, Guo-Hua Gong, Zhe-Shan Quan. Synthesis and evaluation of  the anti-inflammatory activity of quinoline derivatives.  Med Chem Res, 2015, on line

87. Guan LP, Quan ZS. 3,4-DHQLO and Triazole and its Related Analogues with Anticonvulsant Effects. Mini Rev Med Chem. 2015, on line 

 86. Zheng-Qi Dong, Xiao-Mei Liuc, Cheng-Xi Wei* and Zhe-Shan Quanc*. Design, Synthesis of 6-Substituted-pyrido[3,2-d]pyridazine Derivatives with Anticonvulsant Activity. Med Chem, 2015, 11, on line

85. Gong GH, Bian M, Bao SY, Quan ZS*. Anti-maximal electroshock test of agomel. Lat Am J Pharm, 2015,   34 ( 4 ), 641-645     

84. Yu HL, Sun LP, Li MM, Quan ZS. Involvement of norepinephrine and serotonin system in antidepressant-like  effects of oleoylethanolamide in the mice models of behavior despair. Neurosci Lett. 2015, 593, 24-28.

83. Jin P, Yu HL, Tian-Lan, Zhang F, Quan ZS. Antidepressant-like effects of oleoylethanolamide in a mouse   model of chronic unpredictable mild stress. Pharmacol Biochem Behav. 2015, 133:146-154.

82. Shi-Ben Wang, Guang-Chun Piao, Hong-Jian Zhang, Zhe-Shan Quan*. Synthesis of   5-Alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine Derivatives and Evaluation of Their Anticonvulsant    Activities. Molecules, 2015, 20(4):6827-6843

81. Qing-Kun Shen, Shi-Ben Wang, Guo-Hua Gong, Xiu-Mei Yin and Zhe-Shan Quan. Synthesis and Analysis of Anticonvulsant Activities of New 4-[2-(4- alkoxybenzylamino)ethyl]-2H-1,2,4-triazol-3(4H)-one Derivatives.  Lett Drug Des Dis, 2015, 12(5), 430-438

80. Ying-Quan Fang, Chun-Ling Sun, Da-Chuan Liu, Shi-Ben Wang and Zhe-San Quan*. Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4–triazole.  Iran J Pharm Res, 2015,14(1),77-87

2014

79. Yu HL, Feng-Zhang, Tian-Lan, Quan ZS*. Effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine on anticoagulation in mice and the inhibition of experimental thrombosis in rats.  J Cardiovasc Pharmacol. 2014, 64, on line  

78. Shi-Ben WANG, Da-Chuan LIU, Xian-Qing DENG, Guo-Hua GONG* Zhe-Shan QUAN 1*. Synthesis and Evaluation  of  Antidepressant Activities of 5-Alkoxy-6,7,8,9-tetrahydro-benzothieno[3,2-e]tetrazolo[1,5-a]pyrimidine  Derivatives.  Lat Am J Pharm, 2014,33 (7): 1061-1068  

77. Yan-Ping Yuan, Shi-Ben Wang, Guo-Hua Gong,* and Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antibacterial Activities of 1-Alkyl-4-(4H-1,2,4-triazol-4-yl)piperidine Derivatives. Lett Drug Des Dis, 2014, 11, (9): 1070 - 1078 

76. Wang SB, Deng XQ, Liu DC, Zhang HJ, Quan ZS. Synthesis and evaluation of anticonvulsant and antidepressant activities of 7-alkyl-7H-tetrazolo[1,5-g]purine derivatives. Med Chem Res, 2014, 23(10): 4619-4626 

75. Wang SB, Jin P, Li FN, Quan ZS. Synthesis and anticonvulsant activity of novel purine derivatives. Eur J Med Chem, 2014, 84, 574-583

74. Xian-Qing Deng; Ming-Xia Song; Shi-Ben Wang; Zhe-Shan Quan. Synthesis and Anticonvulsant Evaluation of some New 6-(Substitutedphenyl) thiazolo[3,2-b][1,2,4]triazole Derivatives in Mice. Iran J Pharm Res, 2014, 12 (2):  459-469 

73. Li-Jing Cui, Jun Guo, Cheng-Xi Wei*, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 2-Phenyl-2H-benzo[e][1, 3]oxazin-4(3H)-ones. Asian J Chem, 2014, 26(9), 2553-2556

72. Zi-Shi Zhu, Shi-Ben Wang, Xian-Qing Deng, Da-Chuan Liu and Zhe-Shan Quan. Synthesis and Anticonvulsant Activity Evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones. Lett Drug Des Dis, 2014, 11, (5): 628-635

71. Ming-Xia Song, Hong Zeng, Xian-Qing Deng and Zhe-Shan Quan. Synthesis and Evaluation of Anticonvulsant    Activities of Triazole- Incorporated Benzothiazoles. Lett Drug Des Dis, 2014, 11, (4): 488-494 

70. Xian-Qing Deng, Ming-Xia Song,  Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives. J Enzyme Inhib Med Chem, 2014, 29(2): 272-280

69. Da-Chuan Liu, Yan Zheng, Shi-Ben Wang, Zhe-Shan Quan*.Synthesis and Anticonvulsant activity of 7 - alkoxy [1,2,4] triazolo [3,4-b] benzothiazol-3 (2H) – ones. Arch Pharm, 2014, 347, 268-275

68. Xian-Qing Deng, Ming-Xia Song, Yan Zheng, Zhe-Shan Quan. Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. Eur J Med Chem, 2014; 73:217-224

67. Xu Cao, Shi-Ben Wang, Xian-Qing Deng, Da-Chuan Liu, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2, 4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-ones in various murine experimental seizure models. Med Chem Res, 2014, 23: 1829–1838

66. Yan Zheng, Shi-Ben Wang, Xu Cao, Da-Chuan Liu, Bing Shu, Zhe-Shan Quan*. Design, Synthesis and Anticonvulsant Activity Evaluation of Novel 4-(4-Substitutedphenyl)-3-Methyl-1H-1,2,4-Triazol-5(4H)-Ones. Drug Res. (原名:Arzneimittelforschun) 2014, 64(1): 40-46

2013

65. Guo-Hua Gong, Di Wang, J-F Zhang, Cheng-Xi Wei, Zhe-Shan Quan*. Anticonvulsant Activity of 2-(Substituted- imino) thiazolidin-4-ones. Drug Res (原名:Arzneimittelforschun), 2014, 64(1): 5-9

64. Xu Cao, Xian-Qing Deng, Bing Shu, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of 4-(2-alkoxy-phenyl)- 2,4-dihydro- 3H-1,2,4-triazol-3-ones in Various Experimental Seizure Models in Mice. Drug Res. 2013; 63(06): 319-325

63. Yan Zheng, Ming Bian, Xian-Qing Deng, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of 5-Phenyl- [1,2,4] tria-zolo [4,3-c] quinazolin-3-amines. Arch Pharm, 2013, 346(2):119-26 

62. Bing Shu, Yan Zheng, Wang Shi-Ben, Xian-Qing Deng, Zhe-Shan Quan*. Design, Synthesis, and anticonvulsant activity evaluation of  4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones. Arch Pharm, 2013, 346(2):127-33 

61. Yan Zheng, Xian-Qing Deng, Bing Shu, Shi-Ben Wang, Xu Cao and  Zhe-Shan Quan*. Synthesis and Evaluation of the Anticonvulsant Activity of 5-alkylthio-4- phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one Derivatives. Lett Drug Des Dis, 2013, 10, (6): 543-549

60. Ming Bian, Xian-Qing Deng, Guo-Hua Gong, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives. J Enzyme Inhib Med Chem. 2013, 28(4): 792–800.

59. Lan Hong, Guo-Hua Gong, Li Yu, Ming-Xia Song, Xun Cui*, Zhe-Shan Quan*. Synthesis and negative inotropic effects evaluation of 7-substituted-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones. Arch Pharm Res. 2013, 36(11): 1338-1344  

58. Shi-Ben Wang, Xian-Qing Deng, Yan Zheng, Hong-Jian Zhang, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 8-alkoxy-5-(4H-1,2,4-triazol-4-yl)quinoline derivatives. Arch Pharm Res. 2013, 36(1):32-40 

2012

57. Shi-Ben Wang, Xian-Qing Deng, Yan Zheng, Yan-Ping Yuan, Zhe-Shan Quan*, Li-Ping Guan*. Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives. Eur J Med Chem, 2012, 56, 139-144

56. Xian-Qing Deng, Zheng-Qi Dong, Ming-Xia Song, Bing Shu, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and anticonvulsant activities of some triazolothiadiazole derivatives. Arch Pharm . 2012, 345(7), 565-573 

55. Hai-Ling Yu , Feng Zhang, Ying-Jun Li, Guo-Hua Gong, Zhe-Shan Quan*. Anti-inflammatory and antinociceptive effects of 6-(4- chlorophenoxy)-tetrazolo[5,1-a]phthalazine inmice. Pharmacol Rep, 2012, 64(5), 1155-1165

54. Chun-Bo Zhang, Chuan-Wen Yang, Xian-Qing Deng, Zhe-Shan Quan*. Design and synthesis of 6-alkyoxyl[1,2,4] triazolo[1,5-a] quinazoline derivatives with anticonvulsant activity. Med Chem Res, 2012, 21(10), 3294-3300

53. Shi-Ben Wang, Xian-Qing Deng, Ming-Xia Song and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of Some 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazines. Lett Drug Des Dis, 2012, 9(4), 409-414 

52. Nan Jiang, Xian-Qing Deng, Fu-Nan Li ,  Zhe-Shan Quan*. Synthesis of Novel 7-Substituted-5- Phenyl-[1,2,4] triazolo [1,5-a] pyrimidines with Anticonvulsant Activity. Iran J Pharm Res, 2012, 11 (3), 799-806 

2011

51. Xian-Qing Deng, Li-Na Quan, Ming-Xia Song, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. Eur J Med Chem, 2011, 46, 2955-2963

50. Hai-Ling Yu, Xian Qing Deng, Ying-Jun Li, Ying Chun Li, Zhe-Shan Quan*, Xian-Yu Sun. N-palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice. Pharmacol Rep. 2011, 63(3), 834-839

49. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Zhi-Gang Sun, Zhe-Shan Quan*. Synthes is and evaluation of 7-substituted-3,4- dihydrobenzo [f][1,4] oxazepin- 5(2H)-ones as anticonvulsant and hypnotic agents. Med Chem Res, 2011, 20,996-1004 

48. Xian-Qing Deng, Di Wu, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and antidepressant-like action of N-(2-hydroxyethyl)cinnamamide derivatives in mice. Med Chem Res, 2011, 20, 1273-1279

47. Ming-Xia Song, Chun-Bo Zhang, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines. Lett Drug Des Dis, 2011, 8 (9), 769-773 

46. Li-Ping Guan, Xin Sui, Xian-Qing Deng, Dong-Hai Zhao, You-Le Qu, Zhe-Shan Quan*. N-palmitoylethanolamide derivatives: synthesis and studies on anticonvulsant and antidepressant activities. Med Chem Res, 2011, 20,601-605

45. Xian-Qing Deng, Chun-Rui Xiao, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 5-substituted- [1,2,4] triazolo[4,3-a]quinazolines. Chinese J Org Chem, 2011, 31(12), 2082-2087

44. Cheng-Xi Wei, Zhou Guo, Fu-Nan Li,Zhi-Gang Sun, Zhe-Shan Quan*. Design, Synthesis and Anticonvulsant Activity Evaluation of 6-Alkoxy-[1,2,4]triazolo [3,4-a] phthalazin-3(2H)-ones. Asia J Chem, 2011, 24 (1), 127-131

2010

43. Xian-Qing Deng, Cheng-Xi Wei, Fu-Nan Li , Zhi-Gang Sun*, Zhe-Shan Quan*. Design and synthesis of 10-alkoxy-5, 6-dihydro- triazolo[4,3-d]benzo [f][1,4] oxazepine derivatives with anticonvulsant activity. Eur J Med Chem, 2010, 45(7), 3080-3086

42. Xian-Yu Sun, Chuan Hu, Cheng-Xi Wei, Zhi-Gang Sun* Zhe-Shan Quan*. Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives. Eur J Med Chem, 2010, 45(11), 4807-4812

41. Li-Ping Guan*, Xin Sui, Xian-Qing Deng, Ying-Chun Quan, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of a new 6-alkoxy- [1,2,4]triazolo[4,3-b]pyridazine. Eur J Med Chem, 2010, 45(5), 1746–1752

40. Cheng-Xi Wei, Xian-Qing Deng, Kyu-Yun Chai, Zhi-Gang Sun*, and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 1-Formamide-triazolo[4,3-a]quinoline Derivatives. Arch Pharm Res, 2010, 33, 655-662

39. Li-Qiu Zhang, Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Dengand Zhe-Shan Quan*.Synthesis and Anticonvulsant Activity of Some 7-Alkoxy-2H-1,4- benzothiazin- 3(4H)-ones and 7-Alkoxy-4H-[1,2,4]triazolo[4,3-d]benzo[b][1,4]thiazines. Chem Pharm Bull, 2010, 58(3), 326—331

38. Xian-Yu Sun, Cheng-Xi Wei, Xian-Qiang Deng, Zhi-Gang Sun*, Zhe-Shan Quan*.  Evaluation of the anticonvulsant activity of 6-(4-chlorophenyoxy)- tetrazolo[5,1-a] phthalazine in various experimental seizure models in mice. Pharmacol Rep, 2010, 62, 273-277

37. Cheng-Xi Wei, Di Wu, Kyu-Yun Chai, Zhe-Shan Quan*. Synthesis of 6-(3-substituted-4H-1,2,4-triazol-4-yl)- 2-phenylbenzo [d]oxazoles as potential  anticonvulsant agents. Med Chem Res, 2010, 19, 925-935

36. Chuan Hu, Zhi-Gang Sun, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of Some Cinnamylpiperazine Derivatives. Lett Drug Des Discov,2010, 7(5), 661-664

35. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Fu-Nan Li,Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles. Med Chem. 2010, 6(5):313-320.

34. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Kyu-Yun Chai,Zhi-Gang Sun* and Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinolines. Bull Korean Chem Soc. 2010, 31, 447

33. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Zhe-Shan Quan*. Synthesis and antidepressant-like action of 9-alkoxy-7H-furo [3,2-g] chromen-7-ones in mice. Arzneimittelforschun, 2010, 29, 587 

32. Xian-Yu Sun, Cheng-Xi Wei, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and primary anticonvulsant activity evaluation of 6-alkyoxyl- tetrazolo [5,1-a] phthalazine derivatives. Arzneimittelforschung, 2010, 60, (6), 289. 

2009

31. Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Deng, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Eur J Med Chem,  2009, 44(9),  3654-3657

30. Li-Jun Guo, Cheng-Xi Wei, Jing-Hao Jia, Li-Ming Zhao, Zhe-Shan Quan*. Design, Synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Eur J Med Chem, 2009, 44(3), 954-958  

29. Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Piao Huri, Quan Zhe Shan*. Synthesis of 8-Alkoxy-5,6- dihydro-[1,2,4]triazino [4,3-a] quinolin-1-ones With Anticonvulsant Activity, and Assessment of Their Acute Toxicity. Eur J Med Chem, 2009, 44(3), 1265-1270

28. Li-Ping Guan, Dong-Hai Zhao, Jing-Hui Xiu, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and Anticonvulsant activity of N-(2-hydroxyethyl) amide derivatives. Arch Pharm, 2009, 342, 34-40  

27. Wang HJ, Xian-Qing Deng, Cheng-Xi Wei, Li FN, and  Zhe-Shan Quan*. Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinazolines. Arch. Pharm, 2009, 342, 671-675

26. Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao1, Zhe-Shan Quan*. Characterization of the anticonvulsant activity of doxepin in various experimental seizure models in mice. Pharmacol Rep, 2009, 61, 245–251

25. Lei Zhang, Li-Ping Guan, Xian-Yu Sun, Kyu-Yun Chai and Zhe-Shan Quan*. Synthesis and Anticonvulsant activity Evaluation of 6-Alkoxy-[1,2,4] triazolo[3,4-a]phthalazines. Chem Biol Drug Des. 2009, 73, 313-319

24. Xiang-Shu Cui, Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee Young-Ae Ha and Zhe-Shan Quan*. Synthesis and anticonvulsant evaluation of 3- Substituted -4- (4-hexyloxyphenyl)-4H-1,2,4-triazoles. Med Chem Res, 2009, 18, 49-58

23. Cheng-Xi Wei, Li-Ping Guan, Jing-Hao Jia, Kyu-Yun Chai, and Zhe-Shan Quan*. Synthesis of 2-Substituted -6-(4H-1,2,4-triazol-4-yl) benzo[d]oxazoles as Potential Anticonvulsant Agents. Arch Pharm Res, 2009, 32,23-31 

22. Xian-Yu Sun, Li-Ping Guan, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao and Zhe-Shan Quan*. Design. Synthesis and Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]phthalazin-4-one Derivatives. J Brazil Chem Soc, 2009, 20,826-836

21. Li-Ping Guan, Dong-Hai Zhao, Zhe Jiang, Hu-Ri Piao, Zhe-Shan Quan*. Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models. Pharmazie2009,64,248-251

2008

20. Zhong-Tai Piao, Li-Ping Guan, Li-Ming Zhao, Hu-Ri Piao,  Zhe-Shan Quan*. Synthesis of Novel 7-benzyl-amino-2H-benzo[b] [1,4]oxazin-3(4H)-ones as Anticonvulsant Agents.  Eur J Med Chem, 2008, 43, 1216-1221

19. Xian-Yu Sun, Cheng-Xi Wei, KY Chai, Hu-Ri Piao and Zhe-Shan Quan*. Synthesis and anti-inflammatory activities of some novel 7-alkoxy-1-amino-4,5-dihydro-[1,2,4]triazole[4,3-a]quinolines. Arch Pharm, 2008, 341, 288-293

18. Li-Ping Guan, Qing-Hao Jin, Shou-Feng Wang, Fu-Nan Li, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 5-Phenyl[1,2,4]triazolo[4,3-a]quinolines. Arch Pharm, 2008, 341, 774-779   

17. Li-Ping Guan, Guan-Rong Tian, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 1-substituted-7-methoxy-1,2,4-triazolo [4, 3-a]quinoline. Turk J Chem, 2008, 32,181-189  

2007 

16. Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan*. Synthesis and anticonvulsant evaluation of 4-(4-alkoxylphenyl)- 3-ethyl-4H-1,2,4-triazoles as open-chain analogues of 7-alkoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines. Bioorg Med Chem. 2007, 15,6775-81   

15. Cheng-Xi Wei, Fu-Nan Li, Li-Ming Zhao, Zhe-Shan Quan*. Synthesis of 2-substituted-7-heptyloxy-4,5- dihydro-[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with anticonvulsant activity. Arch Pharm, 2007, 340,491   

14. Li-Ping Guan, Qing-Hao Jin, Guan-Rong Tian, KY Chai, Zhe-Shan Quan*. Synthesis of some quinoline-2(1H)-one and [1,2,4]triazolo[4,3-a]quinoline derivatives as potent anticonvulsant. J Pharm Pharm Sci, 2007,10,254-262

13. Yun-Zhe Jin, Li-Ping Guan, Li-Ming Zao, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Study of 7-Substituted Phenoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines and Quinoline- 1 (2 H)-ones. Chinese J Org Chem, 2007, 28(12), 1567-1572    

12. Xiangshu Cui, Liping Guan, Hailan Li, Huri Piao, Zheshan Quan*. Synthesis and anticonvulsant activity of 7-benzylamino- 4,5-dihydro- [1,2,4] triazolo [4,3-a] quinolines*. Prog Nat Sci, 2007, 17, 1104

2006

11. Hong-Guang Jin, Xian-Yu Sun, KY Chai, Hu-Ri Piao and Zhe-Shan Quan*. Anticonvulsant and toxicity evaluation of some 7-alkoxy- 4,5-dihydro- [1,2,4] triazolo[4,3-a]quinoline-1(2H)-ones. Bioorg Med Chem, 2006, 14, 6868-6873 

10. Xian-Yu Sun, Gao Li, CS Jun, KY Chai, Hu-Ri Piao and Zhe-Shan Quan*. Synthesis of 8-alkoxy-4,5-dihydro- [1,2,4] triazole [4,3-a] quinoline-1-ones and evaluation of their anticonvulsant properties. Arch Pharm Res, 2006, 29, 1080-1085 

9. Jun-Min Wang, CS Jun, KY Chai,  KC Kwak, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 1-substituted benzyl- N-substituted- 1,2,3-triazole-4-Formamides. Prog Nat Sci, 2006, 16, 925-929  

2005

8.  Zhi-Feng Xie, KY Chai , Hu-Ri Piao, KC Kwak and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro- [1,2,4] triazolo[4,3-a]quinolines Bioorg Med Chem Lett, 2005, 15, 4803-4805.  

7. Li-Ming Zhao, Hai-Shan Jin, Lian-Peng Sun, Zhe-Shan Quan*. Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives. Bioorg Med Chem Lett. 2005,15,5027-5029    

6. Li-Jing Cui, Zhi-Feng Xie, Hu-Ri Piao, Gao Li, KY Chai. Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 1-Substituted-7- Benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline. Biol Pharm Bull, 2005, 28, 1216-1220          

5. Li-Ping Guan, Ji-Xing Nan, Xue-Jun Jin, Qing-Hao Jin, KC Kwak, KY Chai1 and Zhe-Shan Quan*. Protective Effects of Chalcone Derivants for Acute Liver Injury in Mice. Arch Pharm Res, 2005, 28, 81-86

4. Zhe-Shan Quan*. Jun-Min Wang, JR Rho, KC Kwak, HC Kang CS Jun and Chai Kyu-Yun. Synthesis of 6- alkyloxyl-3,4 -dihydro- 2(1H)-quinoliones and their Anticonvulsant Activities. Bull korea chem Sci, 2005, 26, 1757-1760    

2003-2004

3. Li-Ping Guan, Xiu-Mei Yin, Hong-Mei Quan, Zhe-Shan Quan*. Synthesis of hydroxylated chalcones and related derivatives. Chinese J Org Chem, 2004, 24, 1274-1277  

2. Zhe-Shan Quan*, Li-Ming Zhao, Fu-Nan Li, Hu-Ri Piao. Synthesis of 2,3-disubstituted-5-hydroxybenzofuran derivatives. Chinese J Org Chem, 2004, 24, 1637-1639

1. Zhe-Shan Quan*, Ozaki Y, Kim SW,Hu-Ri Piao. A new synthesis method of 2,5-dialkyl-1,4-benzenediol derivatives. Chinese J Org Chem,2003, 23, 1299-1302