学院概况 机构设置 师资队伍 人才培养 科学研究 党建工作 学生园地 毕业实习
师资队伍 > 教授
全哲山

 

 

 

【研究方向】

   1. 抗癫痫药和抗抑郁药设计与合成

   2. 新药研究与开发

【学习经历】

1981.9-1985.7 延边医学院,药学专业,学士学位

1989.9-1991.7 北京医科大学,药物化学专业,硕士学位

2003.9-2006.2 韩国圆光大学,药物化学专业,博士学位

 

【工作经历】

1981.7-1989.8 延边医学院,药学系,助教

1991.7-1996.12 延边医学院,药学系,讲师

1997.1-2000.12 延边大学,药学院,副教授

1997.1-1997.6  日本城西大学,药学系,访问学者

2001.1-现在   延边大学,药学院,教授

2008.1-现在   延边大学,药学院,博士导师

2012.1-现在   延边大学,药学院,二级教授

【获得荣誉】

    2008年吉林省有突出贡献中青年专业技术人才

    2012年获吉林省拔尖创新人才(第一层次)

    2014年吉林省长白山学者特聘教授

    2014年吉林省高级专家

【社会兼职】

    1.国家自然科学基金委员会评审专家

    2.教育部学位论文评审专家

    3.吉林、河北、内蒙古等科技项目评审专家

    4.中国药物化学杂志编委

    5.延边大学医学学报编委

    6.吉林省药学会药物化学专业委员会委员

【科研项目】 

 

项目名称(编号)

项目来源

承担时间

承担顺序

1

抗癫痫候选药物W112的研究(2012ZX09103-101-044)

国家重大科技专项

2012-2015

1

2

抗癫痫一类新药-Q808胶囊的临床前研究(2011ZX09102-003-03)

国家重大科技专项

2011-2013

2

3

喹啉并四唑类抗抑郁先导化合物的发现与结构优化(81360468)

国家自然科学基金

2014-2017

1

4

喹啉并三唑酮类衍生物的合成及抗癫痫作用研究(81160382)

国家自然科学基金

2012-2014

1

5

吡唑烷酮类衍生物的合成及抗癫痫作用研究(30460151)

国家自然科学基金

2005-2007

1

6

喹喔啉酮衍生物的合成及抗癫痫作用研究(30760290)

国家自然科学基金

2008-2010

1

7

二苯甲基哌嗪类衍生物的合成和抗癫痫作用及作用机制研究(30860340)

国家自然科学基金

2009-2011

1

【获奖】

1.“抗癫痫候选药物Q808的研究”, 吉林省科学技术进步二等奖,吉林省科技厅,2011年,第一名。

2.“吡唑烷酮类抗癫痫先导化合物的寻找与结构优化”,吉林省科学技术进步三等奖,吉林省政府,2006年, 第一名。 

3.三唑类衍生物的合成及抗癫痫作用研究, 吉林省自然科学学术二等奖,吉林省科学技术协会,2014年,第一名。 

4. “7-烷氧基-4,5-二氢[1, 2, 4]三唑并[4, 3-a]喹啉的开链物4-(4-烷氧基苯基)-3-乙基-4H-1,2,4-三唑衍生物的合成及惊厥作用”,吉林省自然科学学术二等奖,吉林省科学技术协会,2009年,第一名。

5. “喹啉及酞嗪并杂环衍生物的合成及抗癫痫作用研究”,吉林省优秀博士论文,2012年,获奖人:孙先宇,指导教师:全哲山

6.“3,4-二氢-苯并[f][1,4]氧氮杂卓衍生物的抗惊厥活性研究”,吉林省优秀硕士论文,2011年,获奖人:邓先清,指导教师:全哲山

7.“三唑环类化合物的合成及其活性的研究”,吉林省优秀硕士论文,2010年,获奖人:陈敬,指导教师:全哲山

8.“7-苄氨基-2H-苯并[b][1,4]氧嗪-3(4H)-酮衍生物的合成及抗惊厥活性评价,2010年,获奖人:朴钟太,指导教师:全哲山  

【申请专利】
1. 全哲山,金洪光,谢志峰,孙先宇,金云哲。用作抗癫痫药的1,2,4-三唑并[4,3-a]喹啉-1-酮衍生物及其可药用盐。中国专利,ZL200610016578.1,2006-07-26(已授权)

 2. 全哲山,邓先清,关丽萍,魏成喜,孙先宇。用作抗抑郁药的5-烷氧基-四唑并[1,5-a]喹啉酮衍生物及其可药用盐,中国专利,200910004690.7

 3. 全哲山,关丽萍,孙先宇,魏成喜,张昌浩。用作抗癫痫药的6-(取代苯氧基)-四唑并[5,1-a]酞嗪衍生物及其可药用盐,中国专利,200810165734.X,2010,3,24(已授权)

 4. 全哲山,宫国华,魏成喜,邓先清,孙先宇。一类用作抗癫痫药的化合物及其可用药用盐,中国专利,201110170659.8,2012,12,19

 5. 全哲山,于海玲,邓先清。化合物 6-(4-氯苯氧基)-四唑并[5,1-a]酞嗪在制备治疗抑郁症药物中的应用,中国专利,201210232371.3,2013,01,23

 6. 全哲山,邓先清,刘大川。用作抗癫痫药的7-烷氧基-[1,2,4]三唑并[3,4-b]并噻唑-3(2H)-酮衍生物及其制备方法,中国专利,201210316306.9,2013,01,23

7. 全哲山, 李伟,芦志刚,于赢洲,邓先清. 一种6-(4-氯苯氧基)-四唑并[5,1-a]酞嗪的多晶型制备方法及其应用.申请号, 2014100597686, 2014.05.28

 8. 李伟, 全哲山, 梅雪峰, 董方言, 叶婵娟, 芦志刚,于赢洲。 一种用于抗癫痫病药物的Q808固体分散体及其制备方法。申请号,2014100642893,2014.05.28 

 9.全哲山,王世本,温翔。用作抗炎药的9-烷基-5,8,9,10-四氢-4H-7-氧杂-2,3,9,11b-四氮杂-环戊二烯并[α]蒽衍生物及其制备方法。申请号,201410469632.2

 

   【发表论文】        

2015

90. Hong-JianZhang1,PengJin2,Shi-BenWang1,Fu-NanLi3,Li-PingGuan4, andZhe-ShanQuan.

   Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-2[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one   and Its Derivatives. Arch Pharm, 2015, on line

 

89. Hui Li, Dong-Zhou Kang*, Shi-Ben Wang, Guo-Hua Gong, Zhe-Shan Quan. Synthesis and elvaluation of the anticonvulsant activity of  9-alkyl-2,9-dihydro-3H-1,2,4-triazolo[4,3-a]benzimidazole-3-one deriva. Lat Am J Pharm, 2015, 34(1), 5-12

 

88. Xiang Wen, Shi-Ben Wang, Da-Chuan Liu, Guo-Hua Gong, Zhe-Shan Quan. Synthesis and evaluation of  the anti-inflammatory activity of quinoline derivatives.  Med Chem Res, 2015, on line

 

87. Guan LP, Quan ZS. 3,4-DHQLO and Triazole and its Related Analogues with Anticonvulsant Effects. Mini Rev Med Chem. 2015, on line 

 

86. Zheng-Qi Dong, Xiao-Mei Liuc, Cheng-Xi Wei* and Zhe-Shan Quanc*. Design, Synthesis of 6-Substituted-

   pyrido[3,2-d]pyridazine Derivatives with Anticonvulsant Activity. Med Chem, 2015, 11, on line

 

85. Gong GH, Bian M, Bao SY, Quan ZS*. Anti-maximal electroshock test of agomel. Lat Am J Pharm, 2015,   34 ( 4 ), 641-645     

 

84. Yu HL, Sun LP, Li MM, Quan ZS. Involvement of norepinephrine and serotonin system in antidepressant-like  effects of oleoylethanolamide in the mice models of behavior despair. Neurosci Lett. 2015, 593, 24-28.

 

83. Jin P, Yu HL, Tian-Lan, Zhang F, Quan ZS. Antidepressant-like effects of oleoylethanolamide in a mouse   model of chronic unpredictable mild stress. Pharmacol Biochem Behav. 2015, 133:146-154.

 

82. Shi-Ben Wang, Guang-Chun Piao, Hong-Jian Zhang, Zhe-Shan Quan*. Synthesis of   5-Alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine Derivatives and Evaluation of Their Anticonvulsant    Activities. Molecules, 2015, 20(4):6827-6843

 

81. Qing-Kun Shen, Shi-Ben Wang, Guo-Hua Gong, Xiu-Mei Yin and Zhe-Shan Quan. Synthesis

and Analysis of Anticonvulsant Activities of New 4-[2-(4- alkoxybenzylamino)ethyl]-2H-1,2,4-

triazol-3(4H)-one Derivatives.  Lett Drug Des Dis, 2015, 12(5), 430-438

80. Ying-Quan Fang, Chun-Ling Sun, Da-Chuan Liu, Shi-Ben Wang and Zhe-San Quan*. Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4–triazole.  Iran J Pharm Res, 2015,14(1),77-87

2014

79. Yu HL, Feng-Zhang, Tian-Lan, Quan ZS*. Effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine on anticoagulation in mice and the inhibition of experimental thrombosis in rats.  J Cardiovasc Pharmacol. 2014, 64, on line  

78. Shi-Ben WANG, Da-Chuan LIU, Xian-Qing DENG, Guo-Hua GONG* Zhe-Shan QUAN 1*. Synthesis and Evaluation  of  Antidepressant Activities of 5-Alkoxy-6,7,8,9-tetrahydro-benzothieno[3,2-e]tetrazolo[1,5-a]pyrimidine  Derivatives.  Lat Am J Pharm, 2014,33 (7): 1061-1068  

77. Yan-Ping Yuan, Shi-Ben Wang, Guo-Hua Gong,* and Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antibacterial Activities of 1-Alkyl-4-(4H-1,2,4-triazol-4-yl)piperidine Derivatives. Lett Drug Des Dis, 2014, 11, (9): 1070 - 1078 

76. Wang SB, Deng XQ, Liu DC, Zhang HJ, Quan ZS. Synthesis and evaluation of anticonvulsant and antidepressant activities of 7-alkyl-7H-tetrazolo[1,5-g]purine derivatives. Med Chem Res, 2014, 23(10): 4619-4626 

75. Wang SB, Jin P, Li FN, Quan ZS. Synthesis and anticonvulsant activity of novel purine derivatives. Eur J Med Chem, 2014, 84, 574-583

74. Xian-Qing Deng; Ming-Xia Song; Shi-Ben Wang; Zhe-Shan Quan. Synthesis and Anticonvulsant Evaluation of some New 6-(Substitutedphenyl) thiazolo[3,2-b][1,2,4]triazole Derivatives in Mice. Iran J Pharm Res, 2014, 12 (2):  459-469 

73. Li-Jing Cui, Jun Guo, Cheng-Xi Wei*, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 2-Phenyl-2H-benzo[e][1, 3]oxazin-4(3H)-ones. Asian J Chem, 2014, 26(9), 2553-2556

72. Zi-Shi Zhu, Shi-Ben Wang, Xian-Qing Deng, Da-Chuan Liu and Zhe-Shan Quan. Synthesis and Anticonvulsant Activity Evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones. Lett Drug Des Dis, 2014, 11, (5): 628-635

71. Ming-Xia Song, Hong Zeng, Xian-Qing Deng and Zhe-Shan Quan. Synthesis and Evaluation of Anticonvulsant    Activities of Triazole- Incorporated Benzothiazoles. Lett Drug Des Dis, 2014, 11, (4): 488-494 

70. Xian-Qing Deng, Ming-Xia Song,  Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives. J Enzyme Inhib Med Chem, 2014, 29(2): 272-280

69. Da-Chuan Liu, Yan Zheng, Shi-Ben Wang, Zhe-Shan Quan*.Synthesis and Anticonvulsant activity of 7 - alkoxy [1,2,4] triazolo [3,4-b] benzothiazol-3 (2H) – ones. Arch Pharm, 2014, 347, 268-275

68. Xian-Qing Deng, Ming-Xia Song, Yan Zheng, Zhe-Shan Quan. Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. Eur J Med Chem, 2014; 73:217-224

67. Xu Cao, Shi-Ben Wang, Xian-Qing Deng, Da-Chuan Liu, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2, 4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-ones in various murine experimental seizure models. Med Chem Res, 2014, 23: 1829–1838

66. Yan Zheng, Shi-Ben Wang, Xu Cao, Da-Chuan Liu, Bing Shu, Zhe-Shan Quan*. Design, Synthesis and Anticonvulsant Activity Evaluation of Novel 4-(4-Substitutedphenyl)-3-Methyl-1H-1,2,4-Triazol-5(4H)-Ones. Drug Res. (原名:Arzneimittelforschun) 2014, 64(1): 40-46

2013

65. Guo-Hua Gong, Di Wang, J-F Zhang, Cheng-Xi Wei, Zhe-Shan Quan*. Anticonvulsant Activity of 2-(Substituted- imino) thiazolidin-4-ones. Drug Res (原名:Arzneimittelforschun), 2014, 64(1): 5-9

64. Xu Cao, Xian-Qing Deng, Bing Shu, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of 4-(2-alkoxy-phenyl)- 2,4-dihydro- 3H-1,2,4-triazol-3-ones in Various Experimental Seizure Models in Mice. Drug Res. 2013; 63(06): 319-325

63. Yan Zheng, Ming Bian, Xian-Qing Deng, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of 5-Phenyl- [1,2,4] tria-zolo [4,3-c] quinazolin-3-amines. Arch Pharm, 2013, 346(2):119-26 

62. Bing Shu, Yan Zheng, Wang Shi-Ben, Xian-Qing Deng, Zhe-Shan Quan*. Design, Synthesis, and anticonvulsant activity evaluation of  4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones. Arch Pharm, 2013, 346(2):127-33 

61. Yan Zheng, Xian-Qing Deng, Bing Shu, Shi-Ben Wang, Xu Cao and  Zhe-Shan Quan*. Synthesis and Evaluation of the Anticonvulsant Activity of 5-alkylthio-4- phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one Derivatives. Lett Drug Des Dis, 2013, 10, (6): 543-549

60. Ming Bian, Xian-Qing Deng, Guo-Hua Gong, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives. J Enzyme Inhib Med Chem. 2013, 28(4): 792–800.

59. Lan Hong, Guo-Hua Gong, Li Yu, Ming-Xia Song, Xun Cui*, Zhe-Shan Quan*. Synthesis and negative inotropic effects evaluation of 7-substituted-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones. Arch Pharm Res. 2013, 36(11): 1338-1344  

58. Shi-Ben Wang, Xian-Qing Deng, Yan Zheng, Hong-Jian Zhang, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 8-alkoxy-5-(4H-1,2,4-triazol-4-yl)quinoline derivatives. Arch Pharm Res. 2013, 36(1):32-40 

2012

57. Shi-Ben Wang, Xian-Qing Deng, Yan Zheng, Yan-Ping Yuan, Zhe-Shan Quan*, Li-Ping Guan*. Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives. Eur J Med Chem, 2012, 56, 139-144

56. Xian-Qing Deng, Zheng-Qi Dong, Ming-Xia Song, Bing Shu, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and anticonvulsant activities of some triazolothiadiazole derivatives. Arch Pharm . 2012, 345(7), 565-573 

55. Hai-Ling Yu , Feng Zhang, Ying-Jun Li, Guo-Hua Gong, Zhe-Shan Quan*. Anti-inflammatory and antinociceptive effects of 6-(4- chlorophenoxy)-tetrazolo[5,1-a]phthalazine inmice. Pharmacol Rep, 2012, 64(5), 1155-1165

54. Chun-Bo Zhang, Chuan-Wen Yang, Xian-Qing Deng, Zhe-Shan Quan*. Design and synthesis of 6-alkyoxyl[1,2,4] triazolo[1,5-a] quinazoline derivatives with anticonvulsant activity. Med Chem Res, 2012, 21(10), 3294-3300

53. Shi-Ben Wang, Xian-Qing Deng, Ming-Xia Song and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of Some 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazines. Lett Drug Des Dis, 2012, 9(4), 409-414 

52. Nan Jiang, Xian-Qing Deng, Fu-Nan Li ,  Zhe-Shan Quan*. Synthesis of Novel 7-Substituted-5- Phenyl-[1,2,4] triazolo [1,5-a] pyrimidines with Anticonvulsant Activity. Iran J Pharm Res, 2012, 11 (3), 799-806 

2011

51. Xian-Qing Deng, Li-Na Quan, Ming-Xia Song, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. Eur J Med Chem, 2011, 46, 2955-2963

50. Hai-Ling Yu, Xian Qing Deng, Ying-Jun Li, Ying Chun Li, Zhe-Shan Quan*, Xian-Yu Sun. N-palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice. Pharmacol Rep. 2011, 63(3), 834-839

49. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Zhi-Gang Sun, Zhe-Shan Quan*. Synthes is and evaluation of 7-substituted-3,4- dihydrobenzo [f][1,4] oxazepin- 5(2H)-ones as anticonvulsant and hypnotic agents. Med Chem Res, 2011, 20,996-1004 

48. Xian-Qing Deng, Di Wu, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and antidepressant-like action of N-(2-hydroxyethyl)cinnamamide derivatives in mice. Med Chem Res, 2011, 20, 1273-1279

47. Ming-Xia Song, Chun-Bo Zhang, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines. Lett Drug Des Dis, 2011, 8 (9), 769-773 

46. Li-Ping Guan, Xin Sui, Xian-Qing Deng, Dong-Hai Zhao, You-Le Qu, Zhe-Shan Quan*. N-palmitoylethanolamide derivatives: synthesis and studies on anticonvulsant and antidepressant activities. Med Chem Res, 2011, 20,601-605

45. Xian-Qing Deng, Chun-Rui Xiao, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 5-substituted- [1,2,4] triazolo[4,3-a]quinazolines. Chinese J Org Chem, 2011, 31(12), 2082-2087

44. Cheng-Xi Wei, Zhou Guo, Fu-Nan Li,Zhi-Gang Sun, Zhe-Shan Quan*. Design, Synthesis and Anticonvulsant Activity Evaluation of 6-Alkoxy-[1,2,4]triazolo [3,4-a] phthalazin-3(2H)-ones. Asia J Chem, 2011, 24 (1), 127-131

2010

43. Xian-Qing Deng, Cheng-Xi Wei, Fu-Nan Li , Zhi-Gang Sun*, Zhe-Shan Quan*. Design and synthesis of 10-alkoxy-5, 6-dihydro- triazolo[4,3-d]benzo [f][1,4] oxazepine derivatives with anticonvulsant activity. Eur J Med Chem, 2010, 45(7), 3080-3086

42. Xian-Yu Sun, Chuan Hu, Cheng-Xi Wei, Zhi-Gang Sun* Zhe-Shan Quan*. Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives. Eur J Med Chem, 2010, 45(11), 4807-4812

41. Li-Ping Guan*, Xin Sui, Xian-Qing Deng, Ying-Chun Quan, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of a new 6-alkoxy- [1,2,4]triazolo[4,3-b]pyridazine. Eur J Med Chem, 2010, 45(5), 1746–1752

40. Cheng-Xi Wei, Xian-Qing Deng, Kyu-Yun Chai, Zhi-Gang Sun*, and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 1-Formamide-triazolo[4,3-a]quinoline Derivatives. Arch Pharm Res, 2010, 33, 655-662

39. Li-Qiu Zhang, Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Dengand Zhe-Shan Quan*.Synthesis and Anticonvulsant Activity of Some 7-Alkoxy-2H-1,4- benzothiazin- 3(4H)-ones and 7-Alkoxy-4H-[1,2,4]triazolo[4,3-d]benzo[b][1,4]thiazines. Chem Pharm Bull, 2010, 58(3), 326—331

38. Xian-Yu Sun, Cheng-Xi Wei, Xian-Qiang Deng, Zhi-Gang Sun*, Zhe-Shan Quan*.  Evaluation of the anticonvulsant activity of 6-(4-chlorophenyoxy)- tetrazolo[5,1-a] phthalazine in various experimental seizure models in mice. Pharmacol Rep, 2010, 62, 273-277

37. Cheng-Xi Wei, Di Wu, Kyu-Yun Chai, Zhe-Shan Quan*. Synthesis of 6-(3-substituted-4H-1,2,4-triazol-4-yl)- 2-phenylbenzo [d]oxazoles as potential  anticonvulsant agents. Med Chem Res, 2010, 19, 925-935

36. Chuan Hu, Zhi-Gang Sun, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of Some Cinnamylpiperazine Derivatives. Lett Drug Des Discov,2010, 7(5), 661-664

35. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Fu-Nan Li,Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles. Med Chem. 2010, 6(5):313-320.

34. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Kyu-Yun Chai,Zhi-Gang Sun* and Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinolines. Bull Korean Chem Soc. 2010, 31, 447

33. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Zhe-Shan Quan*. Synthesis and antidepressant-like action of 9-alkoxy-7H-furo [3,2-g] chromen-7-ones in mice. Arzneimittelforschun, 2010, 29, 587 

32. Xian-Yu Sun, Cheng-Xi Wei, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and primary anticonvulsant activity evaluation of 6-alkyoxyl- tetrazolo [5,1-a] phthalazine derivatives. Arzneimittelforschung, 2010, 60, (6), 289. 

2009

31. Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Deng, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Eur J Med Chem,  2009, 44(9),  3654-3657

30. Li-Jun Guo, Cheng-Xi Wei, Jing-Hao Jia, Li-Ming Zhao, Zhe-Shan Quan*. Design, Synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Eur J Med Chem, 2009, 44(3), 954-958  

29. Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Piao Huri, Quan Zhe Shan*. Synthesis of 8-Alkoxy-5,6- dihydro-[1,2,4]triazino [4,3-a] quinolin-1-ones With Anticonvulsant Activity, and Assessment of Their Acute Toxicity. Eur J Med Chem, 2009, 44(3), 1265-1270

28. Li-Ping Guan, Dong-Hai Zhao, Jing-Hui Xiu, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and Anticonvulsant activity of N-(2-hydroxyethyl) amide derivatives. Arch Pharm, 2009, 342, 34-40  

27. Wang HJ, Xian-Qing Deng, Cheng-Xi Wei, Li FN, and  Zhe-Shan Quan*. Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinazolines. Arch. Pharm, 2009, 342, 671-675

26. Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao1, Zhe-Shan Quan*. Characterization of the anticonvulsant activity of doxepin in various experimental seizure models in mice. Pharmacol Rep, 2009, 61, 245–251

25. Lei Zhang, Li-Ping Guan, Xian-Yu Sun, Kyu-Yun Chai and Zhe-Shan Quan*. Synthesis and Anticonvulsant activity Evaluation of 6-Alkoxy-[1,2,4] triazolo[3,4-a]phthalazines. Chem Biol Drug Des. 2009, 73, 313-319

24. Xiang-Shu Cui, Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee Young-Ae Ha and Zhe-Shan Quan*. Synthesis and anticonvulsant evaluation of 3- Substituted -4- (4-hexyloxyphenyl)-4H-1,2,4-triazoles. Med Chem Res, 2009, 18, 49-58

23. Cheng-Xi Wei, Li-Ping Guan, Jing-Hao Jia, Kyu-Yun Chai, and Zhe-Shan Quan*. Synthesis of 2-Substituted -6-(4H-1,2,4-triazol-4-yl) benzo[d]oxazoles as Potential Anticonvulsant Agents. Arch Pharm Res, 2009, 32,23-31 

22. Xian-Yu Sun, Li-Ping Guan, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao and Zhe-Shan Quan*. Design. Synthesis and Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]phthalazin-4-one Derivatives. J Brazil Chem Soc, 2009, 20,826-836

21. Li-Ping Guan, Dong-Hai Zhao, Zhe Jiang, Hu-Ri Piao, Zhe-Shan Quan*. Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models. Pharmazie2009,64,248-251

2008

20. Zhong-Tai Piao, Li-Ping Guan, Li-Ming Zhao, Hu-Ri Piao,  Zhe-Shan Quan*. Synthesis of Novel 7-benzyl-amino-2H-benzo[b] [1,4]oxazin-3(4H)-ones as Anticonvulsant Agents.  Eur J Med Chem, 2008, 43, 1216-1221

19. Xian-Yu Sun, Cheng-Xi Wei, KY Chai, Hu-Ri Piao and Zhe-Shan Quan*. Synthesis and anti-inflammatory activities of some novel 7-alkoxy-1-amino-4,5-dihydro-[1,2,4]triazole[4,3-a]quinolines. Arch Pharm, 2008, 341, 288-293

18. Li-Ping Guan, Qing-Hao Jin, Shou-Feng Wang, Fu-Nan Li, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 5-Phenyl[1,2,4]triazolo[4,3-a]quinolines. Arch Pharm, 2008, 341, 774-779   

17. Li-Ping Guan, Guan-Rong Tian, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 1-substituted-7-methoxy-1,2,4-triazolo [4, 3-a]quinoline. Turk J Chem, 2008, 32,181-189  

2007 

16. Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan*. Synthesis and anticonvulsant evaluation of 4-(4-alkoxylphenyl)- 3-ethyl-4H-1,2,4-triazoles as open-chain analogues of 7-alkoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines. Bioorg Med Chem. 2007, 15,6775-81   

15. Cheng-Xi Wei, Fu-Nan Li, Li-Ming Zhao, Zhe-Shan Quan*. Synthesis of 2-substituted-7-heptyloxy-4,5- dihydro-[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with anticonvulsant activity. Arch Pharm, 2007, 340,491   

14. Li-Ping Guan, Qing-Hao Jin, Guan-Rong Tian, KY Chai, Zhe-Shan Quan*. Synthesis of some quinoline-2(1H)-one and [1,2,4]triazolo[4,3-a]quinoline derivatives as potent anticonvulsant. J Pharm Pharm Sci, 2007,10,254-262

13. Yun-Zhe Jin, Li-Ping Guan, Li-Ming Zao, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Study of 7-Substituted Phenoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines and Quinoline- 1 (2 H)-ones. Chinese J Org Chem, 2007, 28(12), 1567-1572    

12. Xiangshu Cui, Liping Guan, Hailan Li, Huri Piao, Zheshan Quan*. Synthesis and anticonvulsant activity of 7-benzylamino- 4,5-dihydro- [1,2,4] triazolo [4,3-a] quinolines*. Prog Nat Sci, 2007, 17, 1104

2006

11. Hong-Guang Jin, Xian-Yu Sun, KY Chai, Hu-Ri Piao and Zhe-Shan Quan*. Anticonvulsant and toxicity evaluation of some 7-alkoxy- 4,5-dihydro- [1,2,4] triazolo[4,3-a]quinoline-1(2H)-ones. Bioorg Med Chem, 2006, 14, 6868-6873 

10. Xian-Yu Sun, Gao Li, CS Jun, KY Chai, Hu-Ri Piao and Zhe-Shan Quan*. Synthesis of 8-alkoxy-4,5-dihydro- [1,2,4] triazole [4,3-a] quinoline-1-ones and evaluation of their anticonvulsant properties. Arch Pharm Res, 2006, 29, 1080-1085 

9. Jun-Min Wang, CS Jun, KY Chai,  KC Kwak, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 1-substituted benzyl- N-substituted- 1,2,3-triazole-4-Formamides. Prog Nat Sci, 2006, 16, 925-929  

2005

8.  Zhi-Feng Xie, KY Chai , Hu-Ri Piao, KC Kwak and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro- [1,2,4] triazolo[4,3-a]quinolines Bioorg Med Chem Lett, 2005, 15, 4803-4805.  

7. Li-Ming Zhao, Hai-Shan Jin, Lian-Peng Sun, Zhe-Shan Quan*. Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives. Bioorg Med Chem Lett. 2005,15,5027-5029    

6. Li-Jing Cui, Zhi-Feng Xie, Hu-Ri Piao, Gao Li, KY Chai. Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 1-Substituted-7- Benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline. Biol Pharm Bull, 2005, 28, 1216-1220          

5. Li-Ping Guan, Ji-Xing Nan, Xue-Jun Jin, Qing-Hao Jin, KC Kwak, KY Chai1 and Zhe-Shan Quan*. Protective Effects of Chalcone Derivants for Acute Liver Injury in Mice. Arch Pharm Res, 2005, 28, 81-86

4. Zhe-Shan Quan*. Jun-Min Wang, JR Rho, KC Kwak, HC Kang CS Jun and Chai Kyu-Yun. Synthesis of 6- alkyloxyl-3,4 -dihydro- 2(1H)-quinoliones and their Anticonvulsant Activities. Bull korea chem Sci, 2005, 26, 1757-1760    

2003-2004

3. Li-Ping Guan, Xiu-Mei Yin, Hong-Mei Quan, Zhe-Shan Quan*. Synthesis of hydroxylated chalcones and related derivatives. Chinese J Org Chem, 2004, 24, 1274-1277  

2. Zhe-Shan Quan*, Li-Ming Zhao, Fu-Nan Li, Hu-Ri Piao. Synthesis of 2,3-disubstituted-5-hydroxybenzofuran derivatives. Chinese J Org Chem, 2004, 24, 1637-1639

1. Zhe-Shan Quan*, Ozaki Y, Kim SW,Hu-Ri Piao. A new synthesis method of 2,5-dialkyl-1,4-benzenediol derivatives. Chinese J Org Chem,2003, 23, 1299-1302