闵俊哲，日本静冈县立大学药学博士，三级教授，博士生导师，药物分析学科带头人，“吉林省百名高层次创新创业人才”，“图们江学者”，全国药物分析技术分会常务委员，教育部学位中心博士学位论文评审专家，全国专业学位水平评估函审专家。日本静冈县立大学客座教授。Frontiers in chemistry杂志副主编。赴浙江大学药学院从事“西部之光访问学者”一年（师从曾苏教授）。2021年作为执行主席在延吉成功主办“全国药物分析学科战略发展研讨会”。
现主要致力于“手性代谢组学高灵敏度质谱手性探针试剂的开发及应用”；“糖组学及疾病生物标志物筛选”；“中药/朝药复方制剂物质基础、作用机理研究”；“糖尿病、癌症等慢性疾病早期预警及诊断用非侵袭性试剂盒的开发”。日本任教期间主持完成日本文部科学省项目3项（相当于中国面上项目2项，重点项目1项），其他财团、日本科学技术振兴机构成果推广项目等共3项。现主持和完成国家自然科学基金项目4项（地区3项，面上1项），教育部博士点专项基金1项, 吉林省科技厅重点和教育厅项目共3项。发表SCI论文140余篇，已授权中国、日本发明专利6项。成功开发出三款具有高灵敏度的荧光和质谱探针DBD-M-Pro，4-CEBTPP和d0/d5-BOTC，三款探针由百灵威科技有限公司独家代理销售。已培养“青年图们江学者”等优秀博士、硕士生毕业生50余名。先后获得日本药学会东海支部激励奖，日本色谱学会激励奖。延边朝鲜族自治州科学技术发明奖，吉林省科学技术自然科学奖等荣誉。
【探针产品化】手性和糖链分析领域，三款荧光和质谱探针DBD-M-Pro，4-CEBTPP和d0/d5-BOTC，由百灵威科技有限公司独家销售。网址：
① https://www.jkchemical.com/search/9426277?type=1&pageIndex=1
② https://www.jkchemical.com/search/9426275?type=1&pageIndex=1
③ https://www.jkchemical.com/search/9426280?type=1&pageIndex=1
【联系方式】0433-273-4163；E-mail: junzhemin23@163.com
【研究方向】 手性代谢组学、糖组学、中药及民族药物质基础及代谢通路研究、非侵袭性诊断试剂盒的开发。
【科研项目】
1.基于Endo-CC突变体转糖基反应糖链相对定量新方法的构建及应用 （国家自然科学基金面上；项目编号：82173782；55万）
2.人指甲手性代谢组学新方法的研究及在大肠癌早期预警中的应用 （国家自然科学基金地区；项目编号：32160234；36万）
3.靶标人体头发手性代谢物糖尿病预警监测新方法的研究 （吉林省科技厅重点项目；项目编号：YDZJ202201ZYTS596；20万）
4.基于非特异性酶切同位素标记糖链相对定量新方法的研究及在癌症生物标志物筛选中应用 （国家自然科学基金地区；项目编号：81660594；35万）
5.N-/O-糖链同时定量新方法的研究及在癌症生物标志物筛选中的应用 （吉林省科技厅自然科学基金；项目编号：20160101207JC；10万）
6.靶向识别官能团质谱手性试剂的合成及其在糖尿病未病状态手性生物标志物筛选中的应用 （国家自然科学基金地区；项目编号：81360487；55万）
【代表性论著】
1. Yuxuan Li#, Zhenggen Piao#, Songze Wang, Longhai Cui, Xinyan Li, Jinlong Ma, Chengqiang Han, Xi-Ling Li, Toufeng Jin, Jun Zhe Min*, Screening of glycan biomarkers for early detection of colorectal cancer based on novel isotope labeling relative quantitative method, Journal of Pharmaceutical Analysis, 2025, 101262，IF=8.9，一区
2. Yueying Jin#, Minghui Zhang#, Xi-Ling Li#, Chengqiang Han, Qing Shi, Jun Zhe Min *, A dried sweat spot paper (DSSP) method based on novel mass spectrometry probe labeling for detection and resolution of DL-lactate enantiomers as potential biomarkers for diabetes mellitus, Analytica Chimica Acta, 2024, 1317, 342914. IF=5.7, 一区
3. Xi-Ling Li#, Yuxuan Li#, Shuyun Xiao#, Qingsong Li, Chengqiang Han, Danyang Liu, Tengfei Cui, Xiyang Rao, Kenichiro Todoroki, Guang Yang, Jun Zhe Min*, Stable isotope labeling differential glycans discovery in the serum of acute myocardial infarction by ultrahigh-performance liquid chromatography-quadrupole-Orbitrap high resolution mass spectrometry, Analytica Chimica Acta, 2023, 1264, 341269. IF=6.2, 一区
4. Chao Qi, Yueying Jin, Shengyu Cheng, Lei Di, Xin Wang, Minghui Zhang, Lingli Zhang, Xi-Ling Li, Yu Han, Qingkun Ma, Jun Zhe Min*, A novel UHPLC-MS/MS method for the determination of four α-dicarbonyl compounds in wine and dynamic monitoring in human urine after drinking, Food Research International, 2023, 163, 112170. IF=8.1, 一区
5. Yueying Jin, Shengyu Cheng, Ruobai Liu, Chenglong Yu , Lingli Zhang , Xi-Ling Li , Guanghai Yan, Mingyu Zheng, Jun Zhe Min*, Comprehensive characterization of the chemical composition of Lurong dabu decoction and its absorbed prototypes and metabolites in rat plasma using UHPLC–Q Exactive Orbitrap–HRMS, Food Research International, 2022, 161, 111852. IF=7.425, 一区
6. Yu Han, Xi-Ling Li, Minghui Zhang, Jing Wang, Su Zeng, Jun Zhe Min*, Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis, Journal of Pharmaceutical Analysis, 2022, 12, 815-823. IF =14.026, 一区
7. Qingkun Ma, Xi-Ling Li, Chao Qi, Minghui Zhang, Yan Zheng, Qing Shi, Yueying Jin, Lei Di, Jun Nan, Jun Zhe Min*, Simultaneous determination of chiral thiol compounds and monitoring of dynamic changes in human urine after drinking Chinese Korean ethnic rice wine, Journal of Agricultural and Food Chemistry, 2021, 69, 5416−5427. IF=5.279, 一区
8. Shengyu Cheng#, Minghui Zhang#, Xuanran Cong, Jing Li, Qing Shi, and Jun Zhe Min*, Sweeteners in Diabetes and Blood Glucose Management: Advances, Challenges, and Trends in the Food Industry, Food Reviews International, 2025, 2476153, IF=6.0, 二区
9. Yuxuan Li#, Songze Wang#, Chengqiang Han#, Xi-Ling Li, Jun Zhe Min*, Unlocking the future of colorectal cancer detection: Advances in screening glycosylation-based biomarkers on biological mass spectrometry technology, Journal of Chromatography A, 1738 (2024) 465501. IF= 3.8, 二区
10. Songze Wang#, Xin Zhou#, Xin Wang#, Shengyu Cheng, Xi-Ling Li, Jun Nan, Jun Zhe Min*, Simultaneous determination of free DL-amino acids in human hair with a novel DBD-M-Pro derivatization by UHPLC-HRMS: An application in diabetes patients, Journal of Pharmaceutical and Biomedical Analysis, 2024, 251, 116425. IF=3. 1, 二区
11. Chenglong Yu#, Yuxuan Li#, Xi-Ling Li, Chengqiang Han, Jing Li, Ri Jin, Jun Zhe Min*, Relative quantitation of chiral thiol compounds labeled based on isotope novel mass spectrometry probes: Monitoring of the dynamic changes of chiral thiol compounds in human urine during normal, exercise, and rest recovery states, Journal of Chromatography A, 1719 (2024) 464757. IF= 3.8, 二区
12. Shengyu Cheng#, Songze Wang#, Mingshan Zheng#, Yueying Jin , Jing Li , Minghui Zhang , Xi-Ling Li , Jun Zhe Min*, Simultaneous analysis of natural and artificial sweeteners in sugar-free drinks and urine samples by column-switching UHPLC-charged aerosol detection method, Journal of Chromatography A, 1713 (2024) 464533. IF= 3.8, 二区
13. Lei Di, Shengyu Cheng, Yan Zhu, Yueying Jin, Chao Qi, Lingli Zhang, Minghui Zhang, Xin Wang, Yu Han, Xi-Ling Li, Jun Zhe Min*, Development of a diphenyl sulfide structure derivatization reagent for amino acid enantiomers analysis: Application of dynamic monitoring in human urine after drinking wine, Journal of Chromatography A, 2023, 1688, 463698. IF=4.601, 二区
14. Xi-Ling Li, Chengqiang Han, Miao Luo, Shuyun Xiao, Jing Li, Chenglong Yu, Shengyu Cheng, Yueying Jin, Yu Han, Kenichiro Todoroki, Qing Shi, Jun Zhe Min*, Relative quantitation of glycans in cetuximab using ultra-high-performance liquid chromatography-high-resolution mass spectrometry by Pronase E digestion, Journal of Chromatography A, 1677 2022, 463302. IF=4.601, 二区
15. Shengyu Cheng, Xianglin Xu, Xinxin Kong, Yudi Jiang, Luxuan Mo, Mingxia Li, Yueying Jin, Yu Han, Xi-Ling Li, Toufeng Jin*, Jun Zhe Min*, Monitoring of salicylic acid content in human saliva and its relationship with plasma concentrations, Journal of Pharmaceutical and Biomedical Analysis, 2022, 219, 114961. IF=3.571 二区
16. Xi-Ling Li, Yu Han, Yuan Huang, Xiaoqi Sun, Shuyun Xiao, Jun Zhe Min*, Highly sensitive novel fluorescent chiral probe possessing(S)-2-methylproline structures for the determination of chiral aminocompounds by ultra-performance liquid chromatography withfluorescence: An application in the saliva of healthy volunteer, Journal of Chromatography A, 2022, 1661, 462672. IF=4.601, 二区
【授权发明专利】
1) 氨基官能团化合物及糖链标记带正电荷质谱衍生化试剂
发明人：闵 俊哲, 李喜玲；专利号：ZL 201510470738.9
授权公告日：2017.03.22
2) 氨基官能团手性化合物拆分标记带荧光衍生化试剂
发明人：闵 俊哲, 黄媛，娄喆；专利号：ZL 201710080323.X
授权公告日：2019.05.14
3) 糖链相对定量同位素标记质谱衍生化试剂
发明人：闵 俊哲, 罗苗，石清，肖淑云，许春燕；专利号：ZL 201911406823.3 授权公告日：2023.09.22
【招生硕士、博士研究方向】
体内药物分析/手性代谢组学/糖组学/中药及民族药物质基础及作用机理研究/荧光手性探针合成/靶向官能团质谱探针开发/预警及诊断疾病诊断试剂盒开发。
欢迎对科研具有浓厚兴趣、善于团队合作、敢于挑战、勇于创新、明确自我目标的学生加入《418生物组学分析》课题组开展学术研究。
