中药与民族药学系教授

闵俊哲-简介

发布日期:2020年09月04日   阅读人数:


闵俊哲,药学博士,教授,博士生导师,药学一级博士点药物分析二级学科带头人,吉林省百名高层次创新创业人才图们江学者, 吉林省和全国药物分析技术分会第一届委员,教育部学位中心博士学位论文评审专家,全国专业学位水平评估函审专家日本静冈县立大学客座教授。Frontiers in chemistry杂志Analytical Chemistry副主编。2020年赴浙江大学药学院从事中央组织部 西部之光访问学者一年(师从曾苏教授)。2021年作为执行主席在延吉成功主办全国药物分析学科战略发展研讨会

现主要致力于手性代谢组学高灵敏度质谱手性探针试剂的开发及应用糖蛋白糖链的在线快速、简便、高灵敏度定量分析方法的建立中药/朝药复方制剂物质基础、作用机理及代谢通路研究糖尿病、癌症等慢性疾病早期预警及诊断用非侵袭性试剂盒的开发。日本任教期间主持完成日本文部科学省项目3项(相当于中国面上项目2项,重点项目1项),其他财团、日本科学技术振兴机构成果推广项目等共3项。现主持和完成国家自然科学基金项目4项(地区3项,面上1项),教育部博士点专项基金1, 吉林省科技厅重点和教育厅项目共3项。发表SCI论文120余篇,已授权日本专利3项,国内专利2项,申请公开3项。已培养青年图们江学者等优秀博士毕业生7名,硕士生32名。先后获得日本药学会东海支部激励奖,日本色谱学会激励奖。延边朝鲜族自治州科学技术发明奖,吉林省科学技术自然科学三等奖第七届全国药物分析大会暨第三届药物分析国际论坛“岛津优秀论文二等奖”

 

【联系方式】0433-2436012E-mail: junzhemin23@163.com

【研究方向】 手性代谢组学、糖组学、中药及民族药物质基础及代谢通路研究、非侵袭性诊断试剂盒的开发。

【科研项目】

 1.基于Endo-CC突变体转糖基反应糖链相对定量新方法的构建及应用 (国家自然科学基金面上;项目编号:8217378255万)

 2.人指甲手性代谢组学新方法的研究及在大肠癌早期预警中的应用 (国家自然科学基金地区;项目编号:3216023436万)

 3.靶标人体头发手性代谢物糖尿病预警监测新方法的研究 (吉林省科技厅重点项目;项目编号:YDZJ202201ZYTS59620万)

 4.基于非特异性酶切同位素标记糖链相对定量新方法的研究及在癌症生物标志物筛选中应用 (国家自然科学基金地区;项目编号:8166059435万)

  5.N-/O-糖链同时定量新方法的研究及在癌症生物标志物筛选中的应用 (吉林省科技厅自然科学基金;项目编号:20160101207JC10万)

 6.靶向识别官能团质谱手性试剂的合成及其在糖尿病未病状态手性生物标志物筛选中的应用 (国家自然科学基金地区;项目编号:8136048755万)

 

代表性

 1.Chao Qi, Yueying Jin, Shengyu Cheng, Lei Di, Xin Wang, Minghui Zhang, Lingli Zhang, Xi-Ling Li, Yu Han, Qingkun Ma, Jun Zhe Min*, A novel UHPLC-MS/MS method for the determination of four α-dicarbonyl compounds in wine and dynamic monitoring in human urine after drinking, Food Research International, 2023, 163, 112170. IF 7.425, 1

 2.Yueying Jin, Shengyu Cheng, Ruobai Liu, Chenglong Yu , Lingli Zhang , Xi-Ling Li , Guanghai Yan, Mingyu Zheng, Jun Zhe Min*, Comprehensive characterization of the chemical composition of Lurong dabu decoction and its absorbed prototypes and metabolites in rat plasma using UHPLC–Q Exactive Orbitrap–HRMS, Food Research International, 2022, 161, 111852. IF 7.425, 1

  3.Yu Han, Xi-Ling Li, Minghui Zhang, Jing Wang, Su Zeng, Jun Zhe Min*, Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis, Journal of Pharmaceutical Analysis, 2022, 12, 815-823. IF 14.026, 1

  4.Qingkun Ma, Xi-Ling Li, Chao Qi, Minghui Zhang, Yan Zheng, Qing Shi, Yueying Jin, Lei Di, Jun Nan, Jun Zhe Min*, Simultaneous determination of chiral thiol compounds and monitoring of dynamic changes in human urine after drinking Chinese Korean ethnic rice wine, Journal of Agricultural and Food Chemistry, 2021, 69, 5416−5427. IF 5.279, 1

  5.Yu Han, Haihong Hu, Lushan Yu, Su Zeng, Jun Zhe Min*, Sheng Cai, A duplex-specific nuclease (DSN) and catalytic hairpin assembly (CHA)-mediated dual amplification method for miR-146b detection, Analyst, 2023, 148, 556-561. IF 5.227, 2

  6.Lei Di, Shengyu Cheng, Yan Zhu, Yueying Jin, Chao Qi, Lingli Zhang, Minghui Zhang, Xin Wang, Yu Han, Xi-Ling Li, Jun Zhe Min*, Development of a diphenyl sulfide structure derivatization reagent for amino acid enantiomers analysis: Application of dynamic monitoring in human urine after drinking wine, Journal of Chromatography A, 2023, 1688, 463698. IF 4.601, 2

   7.Xi-Ling Li, Chengqiang Han, Miao Luo, Shuyun Xiao, Jing Li, Chenglong Yu, Shengyu Cheng, Yueying Jin, Yu Han, Kenichiro Todoroki, Qing Shi, Jun Zhe Min*, Relative quantitation of glycans in cetuximab using ultra-high-performance liquid chromatography-high-resolution mass spectrometry by Pronase E digestion, Journal of Chromatography A, 1677 2022, 463302. IF 4.601, 2

 8.Shengyu Cheng, Xianglin Xu, Xinxin Kong, Yudi Jiang, Luxuan Mo, Mingxia Li, Yueying Jin, Yu Han, Xi-Ling Li, Toufeng Jin*, Jun Zhe Min*, Monitoring of salicylic acid content in human saliva and its relationship with plasma concentrations, Journal of Pharmaceutical and Biomedical Analysis, 2022, 219, 114961. IF 3.571  2

 9.Xi-Ling Li, Wenhao Li, Chao Qi, Li-Li Zhao, Wenlong Jin, Jun Zhe Min*, Determination of N-acetyl-DL-leucine in the saliva of healthy volunteers and diabetic patients using ultra-performance liquid chromatography with fluorescence detection, Clinica Chimica Acta, 2022, 526, 66-73. IF 6.314,  2

 10.Xi-Ling Li, Yu Han, Yuan Huang, Xiaoqi Sun, Shuyun Xiao, Jun Zhe Min*, Highly sensitive novel fluorescent chiral probe possessing(S)-2-methylproline structures for the determination of chiral aminocompounds by ultra-performance liquid chromatography withfluorescence: An application in the saliva of healthy volunteer, Journal of Chromatography A, 2022, 1661, 462672. IF 4.601, 2

 11.Qingkun Ma, Xiaoxi Man, Chun-Yan Xu, Jian Huo, Chao Qi, Qing Shi, Jun Nan, Jun Zhe Min*, Simultaneous determination of chiral homocysteine, cysteine and glutathione, in serum from humans at normal and stress states using ultrahigh-performance liquid chromatography coupled to quadrupole-Orbitrap high resolution mass spectrometry, Journal of Chromatography A, 2021, 1642, 462028. IF 4.759, 2

 12.Yueying Jin, Chun-Yan Xu, Jing Wang, Xiaoxi Man, Qing Shi, Fenghuan Nie, Jun Nan*, Jun Zhe Min*, Simultaneous determination of free DL-amino acids in natto with novel fluorescent derivatization by UPLC-FL, Food Analytical Methods, 2021, 14, 1099-1109. IF 3.366, 2

专利

 1)氨基官能团化合物及糖链标记带正电荷质谱衍生化试剂

   

  发明人:闵 俊哲, 李喜玲(授权)

   

   专利号:ZL 201510470738.9    授权公告日:2017.03.22

 

 2)氨基官能团手性化合物拆分标记带荧光衍生化试剂

 发明人:闵 俊哲, 黄媛,娄喆(授权)

 专利号:ZL 201710080323.X    授权公告日:2019.05.14

招生硕士博士研究方向

体内药物分析/手性代谢组学/糖组学/中药及民族药物质基础及作用机理研究/荧光手性探针合成/靶向官能团质谱探针开发/预警及诊断疾病诊断试剂盒开发

欢迎对科研具有浓厚兴趣、善于团队合作敢于挑战勇于创新、明确自我目标的学生加入418精英课题组开展学术研究。

 

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