沈庆坤，1989年生于山东聊城，医学博士，延边大学副教授，博士生导师，中国民族医药学会转化医学分会理事，吉林省药物化学专业委员会委员，国际权威期刊Asian Journal of Pharmaceutical Sciences（影响因子IF=10.7）和Pharmaceutical Science Advances青年编委, Bulletin of Pharmaceutical Research 编委。研究方向为抗肿瘤靶向药物及天然药物研究，主持国家自然科学基金1项、吉林省优秀青年基金1项，吉林省重点研发计划—医药专项1项，图们江计划2项、校级教研项目2项，累计获得科研经费160余万，以第一或者通讯作者发表二区以上SCI论文22篇，其中J Med Chem、Eur J Med Chem等SCI中科院一区（Top期刊）12篇，申请国家发明专利14项，已授权9项。获得两个具有开发价值的候选化合物，目前处于处于临床前研究阶段。吉林省“优秀青年基金”获得者、吉林省“长白英才”青年拔尖人才、吉林省高层次引进人才D类、青年图们江学者、青年图们江学者B类（人才引进）、吉林省优秀博士毕业论文、延边大学五四青年奖章等。
【联系方式】0433-2436020；18844702531；E-mail: qkshen@ybu.edu.cn
【研究方向】
1.天然产物结构修饰及活性研究
2.小分子靶向抗肿瘤药物研究
【主持科研项目】
1. 基于p53-MDM2/HDACs双靶点的冬凌草甲素衍生物的结构优化及抗肿瘤活性研究；国家自然科学基金，2021-2024年，82060628，34万，已结项，主持
2. 雷公藤红素类抗癌候选药物S2109的临床前研究；吉林省科技厅重点研发-医药健康关键技术研发项目，2024-2026年，20240305099YY, 90万，在研，主持（Jilin Province Science and Technology Department Key Research and Development Project (NO. 20240305099YY),
3. 疏水标签靶向IGF2BP1蛋白降解剂的设计与抗肿瘤成药性研究；吉林省优秀青年基金，2025-2027年，20250101055JJ, 15万，在研，主持 (Excellent Youth Talent Fund of Jilin Province，20250101055JJ)
4. 青年图们江学者引进人才(2019年9月-2022年8月)，科研经费20万, 已结项，主持
5. 基于p53-MDM2蛋白-蛋白相互作用的冬凌草甲素的结构修饰及抗肿瘤活性研究（JJKH20220559KJ）, 2022-01--2023-12, 2.5万，已结项，主持
6. 延边大学博士启动基金，基于MDM2/HDACs双靶点抑制作用的冬凌草甲素衍生物的结构修饰及抗肿瘤活性评价（602020087）, 2020-07--2023-07, 6万，已结项，主持
【主持教研项目】
1、案例启发式教学法在药学专业本科教学中的探索与实践，延边大学2024年教学改革研究课题（202426）
2、新质生产力驱动下的“科教融合—拔尖创新”型研究生培养模式研究，2025年研究生教育教学改革研究课题（202525）
【指导学生竞赛】
1、吉林省药学会首届“药盾之光”药学科普大赛，省级优秀奖2次，指导教师；
2、2025年“挑战杯”延边大学大学生课外学术科技作品竞赛二等奖，指导教师；
3、2025年延边大学大学生创新大赛铜奖，指导教师；
4、2022年延边大学第八届“互联网+”大学生创新创业大赛银奖，指导教师；
5、2021年延边大学第八届“互联网+”大学生创新创业大赛铜奖，指导教师；
【部分代表性论文】
(1) Fan-Fan Shang, Qing Lu, Tailiang Lin, Miaoxia Pu, Ruoxuan Xiao, Wanmei Liu, Hao Deng,Hongyan Guo, Zhe-Shan Quan, Chunyong Ding,*and Qing-Kun Shen*. Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer. Journal of Medicinal Chemistry, 2023, 66: 12931-12949. (药物化学权威顶刊SCI 1区)
(2) Hao Deng 1, Qian Xu 1, Guo-Qing Chen, Xing Huang, Jin-Ying Liu, Ya-Lan Wang, Yin-Sheng Quan, Rui Yan, Zhe-Shan Quan**, Qing-Kun Shen*. Design and synthesis of azole derivatives of echinocystic acid as α-glucosidase inhibitors with hypoglycemic activity. European Journal of Medicinal Chemistry, 2025, 289: 117437. (SCI 1区)
(3) Hao Deng 1, Qian Xu 1, Xiao-Ting Li 1, Xing Huang, Jin-Ying Liu, Rui Yan, Zhe-Shan Quan*, Qing-Kun Shen*, Hong-Yan Guo*. Design, synthesis, and evaluation of antitumor activity in Pseudolaric acid B Azole derivatives: Novel and potent angiogenesis inhibitor via regulation of the PI3K/AKT and MAPK mediated HIF-1/VEGF signaling pathway. European Journal of Medicinal Chemistry, 2024, 278: 116813. (SCI 1区)
(4) Hong-Yan Guo1, Xiaoting Li1, Xiao-Tong Sang , Zhe-Shan Quan *, Qing-Kun Shen **. Design and synthesis of forsythin derivatives as anti-inflammatory agents for acute lung injury. European Journal of Medicinal Chemistry, 2024, 267: 116223. (SCI 1区)
(5) Zheng Liu, Xing Huang, Hong-Yan Guo, Lu-Wen Zhang, Yin-Sheng Quan,Fen-er Chen, Qing-Kun Shen**, Zhe-Shan Quan*. Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway. European Journal of Medicinal Chemistry, 2023, 259: 115697. (SCI 1区)
(6) Fan-Fan Shang, Jing Ying Wang, Qian Xu, Hao Deng, Hong-Yan Guo, Xuejun Jin, Xiaoting Li*, Qing-Kun Shen*, Zhe-Shan Quan*. Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1a pathway，European Journal of Medicinal Chemistry, 2021, 220：113474. (SCI 1区)
(7) Qing-Kun Shen, Hao Deng, Shi-Ben Wang, Yu-Shun Tian*, Zhe-Shan Quan*, Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway, European Journal of Medicinal Chemistry, 2019,173: 15-31. (SCI 1区)
(8) Lei Pang , Jin Li , Zheng Liu, Yin-Sheng Quan, He Huan Sui, Yi Jia , Fener Chen, Jung Joon Lee, Peng Liu, Zhe-Shan Quan, Qing-Kun Shen*, Hong-Yan Guo*. In vitro and in vivo biological evaluation of newly synthesized multi-target 20(R)-panaxadiol derivatives for treating Alzheimer’s disease，European Journal of Medicinal Chemistry, 2022, 224: 114825. (SCI 1区)
(9) Yin-Sheng Quan1, Xiaoting Li1, Lei Pang c, Hao Deng a, Fener Chen d, Jung Joon Lee, Zhe-Shan Quan, Peng Liu,*, Hong-Yan Guo*, Qing-Kun Shen*. Panaxadiol carbamate derivatives: Synthesis and biological evaluation as potential multifunctional anti-Alzheimer agents. Bioorganic Chemistry, 2024, 143: 106977 (SCI 1区).
(10) Xing Huang, Zheng Liu, Zhe-Shan Quan*, Hong-Yan Guo*, Qing-Kun Shen*. Synthesis and structure-activity relationship studies of fusidic acid derivatives as anti-inflammatory agents for acute lung injury. Bioorganic Chemistry, 2023, 141:106885 (SCI 1区).
(11) Hong-Yan Guo, ChunMei Jin, Hai-Ming Zhang, Chun-Mei Jin,* Qing-Kun Shen*, and Zhe-Shan Quan. Synthesis and Biological Evaluation of (+)-Usnic Acid Derivatives as Potential Anti-Toxoplasma gondii Agents, J Agric Food Chem, 2019, 67: 9630-9642. (SCI 1区)
(12) Hong-Yan Guo, Yue Xing, Yu-Qiao Sun, Can Liu, Qian Xu, Fan-Fan Shang, Run-Hui Zhang, Xue-Jun Jin, Fener Chen, Jung Joon Lee, Dongzhou Kang* , Qing-Kun Shen*, Zhe-Shan Quan*. Ginsengenin derivatives synthesized from 20(R)-panaxotriol:Synthesis, characterization, and antitumor activity targeting HIF-1 pathway. J Ginseng Res, 2022, 46, 738-749. (SCI 1区)
(13) Hao Deng, Qian Xu, Hong-Yan Guo, Xing Huang, Fener Chen, Lili Jin, Zhe-Shan Quan*, Qing-Kun Shen**, Application of cinnamic acid in the structural modification of natural products: A review, Phytochemistry, 2023, 206: 113532. (SCI 2区)
(14) Miao-Xia Pu, Hong-Yan Guo, Zhe-Shan Quan, Xiaoting Li and Qing-Kun Shen, Application of the Mannich reaction in the structural modification of natural products. Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38(1): 2235095 (SCI 2区)
(15) Xing Huang, Hao Deng, Qing-Kun Shen*, Zhe-Shan Quan*,Tanshinone IIA: Pharmacology, total synthesis, and progress in structure-modifications, Curr Med Chem, 2022, 29: 1959-1989. (SCI 2区)
(16) Qing-Kun Shen#; Guo-Hua Gong#; Gao-Li; Mei-Jin; Li-Hua Cao* and Zhe-Shan Quan*, Discovery and evaluation of novel synthetic 5-alkyl-4-oxo- 4,5-dihydro-[1,2,4] triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti- inflammatory agents, J Enzyme Inhib Med Chem, 2020, 35(1): 85-95. (SCI 2区)
(17) Hong-Yan Guo, Zheng-Ai Chenb, Qing-Kun Shen* and Zhe-Shan Quan*, Application of triazoles in the structural modification of natural products. J Enzyme Inhib Med Chem, 2021, 36(1): 1115-1144. (SCI 2区)
【代表性授权专利】
1、沈庆坤，全哲山，尚凡凡，金学军。一种雷公藤红素衍生物及其制备方法和医用用途。专利号：ZL 2021 1 0102947.3 (已授权，2022年2月25日)
2、沈庆坤，郭红艳，全哲山，桑晓桐。一种连翘苷衍生物及其制备方法和医用用途。专利号：ZL 2022 1 0450591.7 (已授权，2023年7月21)
3、沈庆坤，吴丹，全哲山。一种牛蒡子苷元衍生物、制备方法及应用。专利号：ZL 2022 1 1132063.3 （已授权，2024年3月1日）
