
邢月,延边大学药学院临床药学与药理学系,副教授,医学博士,博士生导师,青年图们江学者B类,吉林省E类人才。2022年6月获得延边大学药学院博士学位。吉林省药学会药理专业委员会委员。近5年主持和参与多项课题,主持国家自然科学基金项目1项,吉林省科技厅项目2项,延边大学博士科研启动基金1项等。在British journal of pharmacology、Pharmacological research、Phytomedicine、Journal of ginseng research等国际药学知名期刊上发表SCI论文30余篇。
【联系方式】
0433-2435945;E-mail: yuexing@ybu.edu.cn
【研究方向】
肿瘤药理、免疫药理、中药药理、药物活性筛选、药效学研究
【科研项目】
1.基于中西医药结合新视角探索薯蓣皂苷靶向ZFP91抗炎分子机制(国家自然科学基金青年基金项目,项目编号:82304834,30万元,2024.01-2026.12,项目负责人)。
2.山药素III靶向ZFP91调控Pro-IL-1β泛素化和Caspase-8炎性体活性的抗炎机制研究(吉林省科技厅项目,项目编号:YDZJ202301ZYTS457,8万元,2023.01-2025.12,项目负责人)。
3.葫芦素B靶向ZFP91调控IL-1B 产生抑制急性肺损伤炎症反应的机制研究(吉林省科技厅项目,项目编号:20240602086RC,12万元,2024.01-2025.12,项目负责人)。
4.高良姜素通过干预ZFP91调控IL-1β分泌的抗炎机制研究(延边大学博士启动基金,项目编号:ydbq202324,6万元,2023.01-2025.12,项目负责人)。
【代表性论著】
1.Convallatoxin inhibits IL-1beta production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1beta ubiquitination and caspase-8 inflammasome activity. British journal of pharmacology. 2022, 179(9): 1887-1907. (第一作者,一区,Top,IF:8.67).
2.Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1alpha and STAT3. Pharmacological research. 2018, 135: 166-180. (第一作者,二区,Top,IF:7.658).
3.Galangin inhibits programmed cell death-ligand 1 expression by suppressing STAT3 and MYC and enhances T cell tumor-killing activity. Phytomedicine. 2023, 116, 154877. (共同通讯作者,一区,Top,IF:7.9).
4.Parthenolide Inhibits Synthesis and Promotes Degradation of Programmed Cell Death Ligand 1 and Enhances T Cell Tumor-Killing Activity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2024, 72, 21013-21029. (共同通讯作者,一区,Top,IF:5.7).
5.Mollugin inhibits IL-1β production by reducing zinc finger protein 91-regulated Pro-IL-1β ubiquitination and inflammasome activity. International Immunopharmacolog. 2025,145, 113757. (共同通讯作者,二区,IF:4.7).
6.Regulatory mechanisms of natural compounds from traditional Chinese herbal medicines on the microglial response in ischemic stroke. Phytomedicine. 2023, 116, 154889. (共同第一作者,一区,Top,IF:7.9).
7.Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway. Journal of ginseng research. 2022, 46(6): 738-749. (共同第一作者,一区,Top,IF:6.06).
8.Panaxadiol inhibits IL-1beta secretion by suppressing zinc finger protein 91-regulated activation of non-canonical caspase-8 inflammasome and MAPKs in macrophages. Journal of ethnopharmacology. 2022, 283: 114715. (共同第一作者,二区,Top,IF:5.195).
9.Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-kappaB and Ras/Raf/MEK pathways. Journal of ethnopharmacology 2021, 273: 113989. (共同第一作者,二区,Top,IF:5.195).