李成,延边大学药学院药剂学系副教授,生命药学博士,硕士研究生导师,临床药师。吉林省药学会药理学专业委员会委员,吉林省民族药专业委员会委员,延边医学会医疗事故技术鉴定专家,曾任延边大学附属医院药学部副主任。主要从事药物新剂型与药代动力学的研究。近几年主持国家自然科学基金项目一项,参与国家自然科学基金项目一项(第二负责人)。在国内外学术刊物上发表了学术论文三十余篇。2013年度获吉林省自然科学学术成果奖二等奖。
【联系方式】
0433-2435065;E-mail: 1838014611@qq.com; licheng@ybu.edu.cn
【研究方向】
药物新剂型与药代动力学研究
【科研项目】
1)纳米金释药系统药代动力学与药效特异性的相关研究(国家自然科学基金;项目编号:81660619;37万元;项目负责人)
2)基于结构的新型PTP1B抑制剂的设计、合成及活性研究(国家自然科学基金;项目编号:81460524;36万元;第二负责人)
【代表性论著】
1. Li Xuena, Wang Huanhui, Zou Xiaotong, Su Hui, Li Cheng*. Methotrexate-loaded folic acid of solid-phase synthesis conjugated gold nanoparticles targeted treatment for rheumatoid arthritis. European Journal of Pharmaceutical Sciences, 2022, 170, 106101.
2. Lu Jun, Ren Hongyan, Choi Jun-Shik, Li Cheng*, Guo Jianpeng*. Effects of aspirin on the bioavailability and pharmacokinetics of repaglinide: possible role of cytochrome P450 3A isoforms inhibition by aspirin. Pharmaceutical Chemistry Journal, 2022, 55, 1151-1156.3.
3. Li Cheng, Choi DH, Choi JS. Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine. J Pharmacokinet Pharmacodyn. 2012; 39: 99-108.
4. Li Cheng, Kim M, Choi HS, Choi JS. Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in Rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by baicalein. Arch Pharm Res. 2011; 34: 1965-1972.
5. Li Cheng, Lim SC, Kim J, Choi JS. Effects of myricetin, an anticancer compound, on the bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats. Eur J Drug Metab Pharmacokinet. 2011; 36: 175-182.
6. Li Cheng, Choi BC, Kim DK, Choi JS. Effects of Curcumin on the Pharmacokinetics of Loratadine in Rats: Possible Role of CYP3A4 and P-glycoprotein Inhibition by Curcumin. Biomol Ther. 2011; 19: 364-370.