李明月,延边大学药学院,讲师,医学博士,硕士生导师。2021年6月获得延边大学药学院医学博士学位。2021年11月被延边大学聘为“青年图们江学者B类”。现就职于延边大学药学院临床药学与药理系,吉林省药学会药理专业委员会委员。近5年主持和参与多项课题,包括国家自然科学基金项目1项,吉林省科技厅项目4项,吉林省教育厅项目1项,延边大学博士科研启动基金1项等。在British journal of pharmacology、Pharmacological research、Journal of ginseng research等国际药学知名期刊上发表SCI论文30余篇。
【联系方式】
0433-2436940;E-mail: myli@ybu.edu.cn
【研究方向】
肿瘤药理、免疫药理、中药药理、药物靶点与活性筛选、药效学研究
【承担科研项目】
1.芒柄花素对葡聚糖硫酸钠诱导的小鼠结肠炎的保护作用(吉林省科技厅项目;项目编号:YDZJ202201ZYTS272; 2022.01-2024.12;项目负责人)
2.松萝酸通过干预上皮-间质转化抑制结直肠癌细胞的增殖、迁移与侵袭的分子机制研究(吉林省教育厅项目;项目编号:JJKH20230641KJ;2023.01-2025.12;项目负责人)
3. 枸杞总黄酮提取物对DSS诱导小鼠结肠炎的改善作用及其机制研究(延边大学博士启动基金;项目编号:ydbq202216;2022.01-2024.12;项目负责人).
4.ZFP91参与调控经典和非经典炎症小体活化及侧金盏花E干预机制研究(国家自然科学基金;项目编号:81760657; 2018.01-2021.12;项目参与人).
5.ZFP91通过MAPK信号通路诱导人单核细胞型淋巴瘤THP1细胞分泌IL-1β的研究(吉林省科技创新人才培育计划优秀青年人才基金项目;项目编号:20180520057JH;2018.01-2019.12;项目参与人).
【代表性论著】
1. Yi Zhong1, Ming Yue Li1, Lizhuo Han, Yi Tai et al. Galangin inhibits programmed cell death-ligand 1 expression by suppressing STAT3 and MYC and enhances T cell tumor-killing activity. Phytomedicine. 116:154877, 2023. (共同第一作者,一区,IF:5.34).
2. Myong Hak Ri1, Ming Yue Li1, Yue Xing, Hong Xiang Zuo et al. Narirutin exerts anti-inflammatory activity by inhibiting NLRP3 inflammasome activation in macrophages. Phytother Res. 2023. (共同第一作者,二区,IF:5.882).
3. Yi zhong, Zhi Hong Zhang, Jing Ying Wang, Yue Xing, Myong Hak Ri, Hong Lan Jin, Hong Xiang Zuo, Ming Yue Li*, Juan Ma*, Xuejun Jin*. Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. Toxicology Letters. 356:75-88, 2022. (共同通讯作者,二区,IF:4.374).
4. Yue Xing, Jing Ying Wang, Ming Yue Li, Zhi Hong Zhang, Hong Lan Jin, Hong Xiang Zuo, Juan Ma* and Xuejun Jin*. Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity. Br J Pharmacol.2022 (一区,Top,IF:9.473).
5. Zhi Hong Zhang1, Ming Yue Li1, Zhe Wang, Hong Xiang Zuo, Jing Ying Wang, Yue Xing, Chenghua Jin, Guanghua Xu, Lianxun Piao, Hongxin Piao, Juan Ma*, Xuejun Jin*. Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer. Phytomedicine. 68:153172, 2020. (共同第一作者,二区,IF:5.882).
6. Ming Yue Li, Zhi Hong Zhang, Zhe Wang, Hong Xiang Zuo, Jing Ying Wang, Yue Xing, Cheng Hua Jin, Guang Hua Xu, Lian Xun Piao, Juan Ma*, Xuejun Jin*. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacological Research.147:104355, 2019. (第一作者,一区,IF:7.658).
7. Chunliu Mi, Zhe Wang, Ming Yue Li, Zhi Hong Zhang, Juan Ma and Xuejun Jin. Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome. British Journal of Pharmacology. 175:4338–4352, 2018 (一区,Top,IF:9.473).
8. Ming-Yue Li, Chunliu Mi, Ke Si Wang, Zhe Wang, Hong Xiang Zuo, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Juan Ma*, Xuejun Jin*. Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1 a signaling. Chemico-Biological Interactions. 274:58-67,2017. (第一作者,二区,IF:5.194)